Results 51 to 60 of about 19,998 (234)

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Formulas Involving Cauchy Polynomials, Bernoulli Polynomials, and Generalized Stirling Numbers of Both Kinds

Axioms
In this paper, we derive novel formulas and identities connecting Cauchy numbers and polynomials with both ordinary and generalized Stirling numbers, binomial coefficients, central factorial numbers, Euler polynomials, r-Whitney numbers, and ...
José L. Cereceda
doaj   +1 more source

Voluntary Collective Action to Address Growing Agricultural Challenges in Two Countries: Experimental Insights and Commonalities

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We conducted two framed field economic experiments with citrus farmers in Florida, United States and soybean farmers in Argentina to investigate their willingness to coordinate pest and weed management efforts. Despite the contrast between these two agricultural contexts, we find striking behavioral commonalities.
Ariel Singerman, Sergio H. Lence
wiley   +1 more source

An identity for the central binomial coefficient

, 2012
We find the joint distribution of three simple statistics on lattice paths of n upsteps and n downsteps leading to a triple sum identity for the central binomial coefficient {2n}-choose-{n}. We explain why one of the constituent double sums counts the irreducible pairs of compositions considered by Bender et al., and we evaluate some of the other sums.
openaire   +2 more sources

Agricultural Diversification at the Margin. Strategies and Determinants in Italian Mountain and Remote Areas

Agribusiness, EarlyView.
ABSTRACT This paper explores the convergence in on‐farm diversification strategies of agricultural holdings, between remote areas and more central ones. Using Italian farm‐level data, we explore the determinants of diversification strategies across farms.
Gianluca Grilli, Francesco Pagliacci, Paola Gatto   +2 more
wiley   +1 more source

Modified Generalized Stirling Numbers and Their Matrix Representation

Alfarama Journal of Basic & Applied Sciences
This paper presents a comprehensive study of advanced classes of Stirling numbers within combinatorial analysis and discrete mathematics. The first class examined is the Comtet non-central Stirling numbers of the first and second kinds, which extend the ...
Beih El desouky, Maha Abdelghany Mohamed
doaj   +1 more source

Two permutation classes enumerated by the central binomial coefficients

, 2013
We define a map between the set of permutations that avoid either the four patterns $3214,3241,4213,4231$ or $3124,3142,4123,4132$, and the set of Dyck prefixes. This map, when restricted to either of the two classes, turns out to be a bijection that allows us to determine some notable features of these permutations, such as the distribution of the ...
BARNABEI, MARILENA, BONETTI, FLAVIO, SILIMBANI, MATTEO   +2 more
openaire   +4 more sources

Livelihood Diversification as an Adaptation Strategy to Climate Change and Household Food Security of Livestock Holders in Pakistan

Agribusiness, EarlyView.
ABSTRACT Rural farm households continue to face significant risks from climate change, resulting in many of them diversifying their livelihood sources into other income‐generating activities to increase their incomes and improve food and nutrition security. In this study, we examine the drivers and impact of farm households' participation in livelihood
Mahwish Arshad, Awudu Abdulai
wiley   +1 more source