Results 41 to 50 of about 105,243 (258)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Relationship Between Cervical Central Canal and Neural Foraminal Dimensions in a Normative Population

Tomography
Background/Objectives: The relationship between cervical central canal and neural foraminal dimensions remains undefined. This study examined correlations between these structures in a young adult CT cohort screened to exclude apparent cervical spinal ...
Kai Nguyen, Zachary Brandt, David Shin, Carson Cummings, Rohan Kubba, Jacob Razzouk, Davis Carter, Mei Carter, Wayne Cheng, Olumide Danisa   +9 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Intranasal scopolamine affects the semicircular canals centrally and peripherally

Journal of Applied Physiology, 2015
Space motion sickness (SMS), a condition caused by an intravestibular conflict, remains an important obstacle that astronauts encounter during the first days in space. Promethazine is currently the standard treatment of SMS, but scopolamine is used by some astronauts to prevent SMS.
Weerts, Aurélie P., Putcha, Lakshmi, Hoag, Stephen W., Hallgren, Emma, Van Ombergen, Angelique, Van de Heyning, Paul H., Wuyts, Floris L.   +6 more
openaire   +4 more sources

Central Integration of Canal and Otolith Signals is Abnormal in Vestibular Migraine [PDF]

Frontiers in Neurology, 2014
Vestibular migraine (VM), a common cause of vestibular symptoms within the general population, is a disabling and poorly understood form of dizziness. We sought to examine the underlying pathophysiology of VM with three studies, which involved the central synthesis of canal and otolith cues, and present preliminary results from each of these studies ...
Susan eKing, Susan eKing, Joanne eWang, Adrian ePriesol, Richard eLewis   +4 more
openaire   +5 more sources

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Cone beam computed tomographic–Based retrospective study on newark population for the assessment of distance between incisive canal and maxillary central incisors: Clinical implications

Indian Journal of Dental Research, 2020
Aims: To calculate the relative distance between the incisive canal and maxillary central incisors using cone beam computed tomography (CBCT) and utilize the results in treatment planning in a clinical setting.
Sonam Khurana, Parv Parasher, Padma Mukherjee, Mel Mupparapu, Priti P Lotlikar, Adriana G Creanga   +5 more
doaj   +1 more source

Morphology of root canal surface: A reflection on the process of cementation of the composite relined glass fiber post

Indian Journal of Dental Research, 2017
Background: The present study was conducted to evaluate the bond strength in the different root thirds (premolars and maxillary central incisors) of composite relined glass fiber posts compared to untreated glass fiber posts cemented with dual- or ...
Yasmine Mendes Pupo, Elaine Casacqui, Paola Andressa Barbosa de Lima, Milton Domingos Michél, Albano Luis Novaes Bueno, André Luiz da Costa Michelotto   +5 more
doaj   +1 more source