Results 111 to 120 of about 60,453 (293)

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Comparative Evaluation of Four Stereotactic Radiosurgery Planning Approaches for Treatment of Posterior Choroidal Melanoma

Journal of Medical Radiation Sciences, EarlyView.
This study evaluated four stereotactic radiosurgery planning approaches for posterior choroidal melanoma (CM). Analysis of thirteen CM cases resulted in a clinically meaningful reduction in dose to the brain for Brainlab Elements modulated arcs (BE) and Varian Eclipse HyperArc modulated arcs (HA) compared to Brainlab iPlan dynamic conformal arc therapy
Robert Nigro, Kenton Thompson, Cathy Markham, Adam U. Yeo, Daniel Sapkaroski, Claire Phillips   +5 more
wiley   +1 more source

Normative distribution of corneal epithelial thickness on 9-mm OCT maps

Frontiers in Medicine
This prospective observational study comprehensively characterized the normative distribution of corneal epithelial thickness using 9-mm spectral-domain optical coherence tomography (SD-OCT) maps.
Claudia R. Morgado, Marcony R. Santhiago
doaj   +1 more source

CORNEAL CHANGES IN A SAMPLE OF PSEUDOEXFOLIATION IRAQI PATIENTS

The Iraqi Journal of Medical Sciences, 2018
Background: Pseudoexfoliation syndrome is a common eye disorder that can affect different parts of the eye causing significant morbidity. Objective: To compare corneal endothelial changes between patients with pseudoexfoliation syndrome and ...
Ahmed Rasheed, Diyar Kadum
doaj   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Airway Involvement in Conradi–Hünermann–Happle Syndrome: A Novel Clinical Manifestation

The Laryngoscope, EarlyView.
We report the first documented case of airway involvement in Conradi–Hünermann–Happle syndrome (CDPX2), an X‐linked dominant form of chondrodysplasia punctata caused by pathogenic variants in EBP. A 2‐month‐old female with genetically confirmed CDPX2 developed severe subglottic stenosis and persistent respiratory distress requiring CPAP; cross ...
Enrique G. Villarreal, Jackie Chiang, Evan J. Propst, Nikolaus E. Wolter   +3 more
wiley   +1 more source

Corneal and epithelial thickness mapping in diabetic patients using optical coherence tomography

Journal of the Egyptian Ophthalmological Society
Purpose To evaluate corneal and epithelial thickness using the anterior segment optical coherence tomography and to correlate these changes with major disease parameters, that is duration of the disease, status of control (glycated hemoglobin level), and
Menna A.M Abdel Twaab, Heba el Gendy, Mohamed M El-Sayed, Shaimaa A Arfeen   +3 more
doaj   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Central Corneal Thickness and Glaucoma

Current Journal of Glaucoma Practice with DVD, 2009
In routine clinical practice, central corneal thickness, CCT, represents one of several important parameters used not only in the diagnosis of glaucoma but also for following the progression of this disease and its response to treatment. It also has immense clinical impact in planning refractive surgeries.
openaire   +1 more source