Results 211 to 220 of about 129,033 (293)

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4246-4266, August 2026.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

A study to determine the effect of hydroxychloroquine (HCQ) on central corneal thickness (CCT) in patients with rheumatoid arthritis (RA). [PDF]

Indian J Ophthalmol
Jaichander RC, Thomas RK, Shobha V.
europepmc   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, Volume 38, Issue 8, Page e488-e495, August 2026.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source

Central Corneal Thickness and Endothelial Cell Changes in Diabetics and Age-Matched Non-diabetics in a Tertiary Care Hospital in Central India. [PDF]

Cureus
Daigavane S, Mallareddy V.
europepmc   +1 more source

Contrast Agents for Enhanced Bioimaging: A Comprehensive Review

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube, Donald Fernandes, Arthur Abinader Vasconcelos, Hugo de Campos Braga, Alan Kelbis Oliveira Lima, José Arnaldo Santana Costa, Karla Furtado Andriani, Ester da Cunha Meira Santos, Antonio Jorge Silva Araújo Junior, Hauster Maximiler Campos de Paula, Wallace Júnio Reis, Kashif Gul, Nida Wahab, Luis Carlos Resio, Elisa Kawana Leal dos Santos, Márcio Peres de Araujo, Matheus Allen P. da Silva, Juliana Paula da Silva   +17 more
wiley   +1 more source

Personalized eye protection for head CT organ‐based tube current modulation: A deep learning approach to derive 3D eyeball models from a single‐view topogram

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background The lens of the eye is highly radiosensitive, yet personalized shielding during head CT remains challenging due to the lack of a rapid, pre‐scan localization method. Purpose To develop and validate a deep learning solution that enables automated, patient‐specific eye protection by generating a precise 3D eyeball model directly from ...
Xiaolin Meng, Lei Zhu, Shenghao Chen, Manhua Liu, Yang Wang   +4 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis. [PDF]

PLoS One
Mejía-Salgado G, Muñoz-Vargas PT, Cifuentes-González C, Flórez-Esparza G, Paquentín-Jiménez R, Castro-Monreal MÁ, Medina-Galindo N, Hernández-Herrera GN, Concha-Del-Río LE, de-la-Torre A.   +9 more
europepmc   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear. METHODS In 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free‐water–corrected diffusion MRI ...
Anna S Lorenz, Aditi Sathe, Yisu Yang, Alaina Durant, Yiyang Wu, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Praitayini Kanakaraj, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan Dumitrescu, Niranjana Shashikumar, Kimberly R. Pechman, Shannon L. Risacher, Lori L. Beason‐Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Mohamad Habes, Di Wang, Duygu Tosun, Arthur W. Toga, Paul M. Thompson, Elizabeth C. Mormino, Panpan Zhang, Kurt Schilling, Marilyn Albert, Walter Kukull, Sarah A. Biber, Bennett A. Landman, Sterling C. Johnson, Barbara Bendlin, Julie Schneider, David A. Bennett, Angela L. Jefferson, Susan M. Resnick, Andrew J. Saykin, Jennifer E. Below, Timothy J. Hohman, Derek B. Archer, Alzheimer's Disease Neuroimaging Initiative (ADNI), The BIOCARD Study Team (BIOCARD), The Alzheimer's Disease Sequencing Project (ADSP)   +47 more
wiley   +1 more source