Results 231 to 240 of about 60,453 (293)

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Tumor‐Bearing Status Accelerates Bleomycin‐Induced Pulmonary Inflammation via Endothelial Activation

Thoracic Cancer, Volume 17, Issue 7, April 2026.
In subcutaneous tumor‐bearing mice, inflammatory cell infiltration into the lung was aggravated via endothelial activation. The tumor‐bearing status additively aggravated BLM‐induced lung inflammation. Proinflammatory changes in the lungs accelerated by tumor‐bearing status might be involved in the development of drug‐induced lung inflammation ...
Shoko Isoyama, Kakuhiro Yamaguchi, Hiroshi Iwamoto, Yasushi Horimasu, Kunihiko Funaishi, Kiyofumi Shimoji, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, Hironobu Hamada, Noboru Hattori   +11 more
wiley   +1 more source

Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis. [PDF]

PLoS One
Mejía-Salgado G, Muñoz-Vargas PT, Cifuentes-González C, Flórez-Esparza G, Paquentín-Jiménez R, Castro-Monreal MÁ, Medina-Galindo N, Hernández-Herrera GN, Concha-Del-Río LE, de-la-Torre A.   +9 more
europepmc   +1 more source

Exercise intensity‐dependent cardiac telocyte expansion is associated with physiological growth despite JAK/STAT pathway inactivity in male Wistar rats

Experimental Physiology, Volume 111, Issue 4, Page 1766-1780, 1 April 2026.
Abstract While exercise induces physiological cardiac growth, the underlying cellular mechanisms remain incompletely understood. This study investigated the role of cardiac telocytes (TCs) and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in mediating exercise intensity‐dependent cardiac adaptation.
Mahboobeh Borjian Fard, Siroos Choobineh, Rahman Soori, Zohreh Mazaheri   +3 more
wiley   +1 more source

Low‐dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice

The Journal of Physiology, Volume 604, Issue 7, Page 2845-2866, 1 April 2026.
Abstract figure legend Low‐dose lithium supplementation in ovariectomized mice enhances skeletal muscle contractility (isometric force and fatigue resistance), SERCA function and promotes favourable transcriptional reprogramming, while increasing bone density and modestly improving insulin sensitivity.
Bianca M. Marcella, Jessica L. Braun, Amélie A.T. Marais, Briana L. Hockey, Mia S. Geromella, Ryan W. Baranowski, Rene Vandenboom, Rebecca E.K. MacPherson, Val A. Fajardo   +8 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Soluble epoxide hydrolase (sEH) inhibition enhances corneal wound healing following alkali injury. (A) Schematic representation of corneal injury induced by NaOH or ammonia showing elevated sEH expression in corneal keratocytes. This leads to rapid hydrolysis of epoxy fatty acids (EpFAs), reducing their bioavailability and contributing to enhanced ...
Xiaowen Lu, Christophe Morisseau, Khushi Jain, Zhong Chen, Amy J. Estes, Darryl Zeldin, Artiom Gruzdev, Aniqa Ahmed, Haley Cook, Bruce D. Hammock, Mitchell A. Watsky   +10 more
wiley   +1 more source

Development of a proptosis model as a surgical training tool for veterinary students and practitioners

Veterinary Record, Volume 198, Issue 7, Page e293-e298, 28 March–11 April 2026.
Abstract Background Effective training is fundamental to the development of critical skills for emergency veterinary interventions. This study presents a synthetic canine proptosis model designed to train veterinary interns, final‐year students and practitioners, offering an ethical, reproducible and high‐fidelity option for learning proptosis ...
Oren Pe'er, Lionel Sebbag, Ron Ofri
wiley   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Common TGF beta 2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma [PDF]

, 2012
Fraser, S, Jamshidi, Y, Park, S, Sowden, JC, Vaideanu, D   +4 more
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