Results 71 to 80 of about 7,437,347 (299)
OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD
Advanced Science, EarlyView.This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li +11 more
wiley +1 more source
Central corneal thickness and post-menstrual age.
, 2018 CCT: central corneal thickness. PMA: post-menstrual age. *CCT decreased with PMA (p = 0.040).
Lea-Yea Chuang (299477) +5 more
core +1 more source
TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss
Advanced Science, EarlyView.TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale +23 more
wiley +1 more source
Is the central corneal thickness of diabetic patients thicker than that of non-diabetics’ eyes?
African Vision and Eye Health, 2015 The purpose of the study was to evaluate central corneal thickness in diabetic patients and to compare the results with controls without diabetes mellitus.
Solani D. Mathebula +1 more
doaj +1 more source
Corneal endothelial cell morphometry and corneal thickness in diabetic contact lens wearers
, 2004 Purpose. To assess corneal endothelial cell morphometry and corneal thickness in diabetic patients who wear contact lenses. Methods. Images of the central corneal endothelium were analyzed quantitatively and qualitatively and corneal thickness was ...
NATHAN EFRON +3 more
core +1 more source
Advanced Science, EarlyView.TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu +12 more
wiley +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
ESTIMATION OF MEAN CENTRAL CORNEAL THICKNESS USING SIRIUS SCHEIMPFLUG–PLACIDO TOPOGRAPHER IN BASRAH [PDF]
Basrah Journal of Surgery, 2017 ESTIMATION OF MEAN CENTRAL CORNEAL THICKNESS USING SIRIUS SCHEIMPFLUG–PLACIDO TOPOGRAPHER IN BASRAH Aymen Majeed Fadil* & Salah Zuhair Al-Asadi@ *FIBMS Ophthalmology, Basrah General Hospital.
Aymen Majeed Fadil +1 more
doaj +1 more source
Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Advanced Science, EarlyView.A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li +9 more
wiley +1 more source
Preoperative refraction, central corneal thickness, and estimated thickness of residual stroma.
, 2016 Preoperative refraction, central corneal thickness, and estimated thickness of residual stroma.
Miao He (148269) +3 more
core +1 more source