Results 81 to 90 of about 129,033 (293)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Nature Genetics, 2013
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide ...
Yi Lu, V. Vitart, K. Burdon, C. Khor, Y. Bykhovskaya, Alireza Mirshahi, A. Hewitt, A. Hewitt, D. Koehn, P. Hysi, W. Ramdas, T. Zeller, E. Vithana, Belinda K. Cornes, W. Tay, E. Tai, Ching-Yu Cheng, Jianjun Liu, Jianjun Liu, J. Foo, S. Saw, G. Thorleifsson, Kári Stefánsson, Kári Stefánsson, D. Dimasi, R. Mills, Jenny Mountain, W. Ang, René Hoehn, V. Verhoeven, F. Grus, R. Wolfs, R. Castagné, K. Lackner, Henriët Springelkamp, Jian Yang, Fridbert Jonasson, D. Leung, Li Chen, C. Tham, I. Rudan, I. Rudan, Z. Vatavuk, C. Hayward, J. Gibson, A. Cree, A. Macleod, Sarah Ennis, O. Polašek, Harry Campbell, James F. Wilson, Ananth C. Viswanathan, Brian W. Fleck, Xiaohui Li, D. Siscovick, K. Taylor, J. Rotter, S. Yazar, Megan Ulmer, Jun Li, B. Yaspan, A. B. Ozel, J. E. Richards, S. Moroi, Jonathan L. Haines, Jae-Hoon Kang, L. Pasquale, L. Pasquale, R. Allingham, A. Ashley-Koch, Paul A. Mitchell, J. Wang, Alan F. Wright, C. Pennell, Timothy D. Spector, Terri L. Young, Terri L. Young, C. Klaver, Nicholas G. Martin, Grant W. Montgomery, Michael G. Anderson, Tin Aung, C. Willoughby, J. Wiggs, C. Pang, U. Thorsteinsdóttir, U. Thorsteinsdóttir, A. Lotery, Christopher J. Hammond, C. Duijn, M. Hauser, Y. Rabinowitz, Norbert Pfeiffer, D. Mackey, D. Mackey, J. Craig, S. MacGregor, T. Y. Wong, T. Y. Wong   +98 more
semanticscholar   +1 more source

Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson

Communications Biology, 2020
Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus.
Yoshikatsu Hosoda, M. Miyake, A. Meguro, Y. Tabara, Sachiko Iwai, Naoko Ueda-Arakawa, E. Nakano, Yuki Mori, Munemitsu Yoshikawa, Hideo Nakanishi, C. Khor, S. Saw, R. Yamada, F. Matsuda, Ching-Yu Cheng, N. Mizuki, A. Tsujikawa, K. Yamashiro, Yasuharu Takahisa Kazuya Fumihiko Yoshimitsu Takeo Shinji Tabara Kawaguchi Setoh Matsuda Takahashi Nakayama , T. Kawaguchi, K. Setoh, Yoshimitsu Takahashi, T. Nakayama, S. Kosugi   +23 more
semanticscholar   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

The frequency of non-pathologically thin corneas in young healthy adults

Clinical Ophthalmology, 2019
Hannah Rashdan, Manali Shah, Danielle M RobertsonDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USAPurpose: Measurement of normal corneal thickness and corneal epithelial thickness is important in keratorefractive surgery ...
Rashdan H, Shah M, Robertson DM
doaj  

Distribution of Central Corneal Thickness and its Association with Ocular Parameters in a Large Central European Cohort: The Gutenberg Health Study

PLoS ONE, 2013
Main objective To evaluate the distribution of central corneal thickness (CCT) in a large German cohort and to analyse its relationship with intraocular pressure and further ocular factors. Design Population-based, prospective, cohort study.
E. Hoffmann, J. Lamparter, A. Mirshahi, H. Elflein, René Hoehn, C. Wolfram, K. Lorenz, Max Adler, P. Wild, A. Schulz, Barbara Mathes, M. Blettner, N. Pfeiffer   +12 more
semanticscholar   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Relationship between central corneal thickness, intra ocular pressure and visual field in normal tension and primary open angle glaucoma

مجله دانشگاه علوم پزشکی گرگان, 2012
Background and Objective: Glaucoma is one of the most important cause of blindness wordwide. Exact determination of intra ocular pressure is important for the diagnosis and decision making about glaucoma treatment. Central corneal thickness is considered
Mahjoob M (MSc), Validam MH (MD), Azimi Khorasani A (PhD), Shahrakipoor M (PhD), Momeni Moghadam H (MSc), Nejati J (MSc), Tavakoli A (BSc), Moradgholi M (BSc), Kamali P (BSc), Sargazi M (BSc)   +9 more
doaj  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source