Results 111 to 120 of about 7,950,860 (300)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
South Slav-Russian Relations in the Last Half of the Nineteenth Century
Central Europe, 2020 This article examines the myth of “eternal friendship” between Bulgarians and Russians and how their mutual failure to understand the other’s motives gave way to resentment, estrangement, and mutual naiveté, straining this supposed natural affinity.
David J Crockett
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Notes on Central Europe from Sociological Perspective
, 2007 The following article is an attempt to establish whether the Central Europe of the 20th century is indeed a specific, internally homogenous socio-cultural macro-region. Two mutually complementary approaches were used. One is an analysis of the measure of
Jiří Musil
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Privileged Interfirm/Bank Relationships in Central Europe: Trigger or Trap for Corporate Governance? [PDF]
The paper focuses on the question whether banks and capital markets in Central Europe are capable of exerting a positive influence on enterprise performance at the present stage of the economic transformation.
Gerhard Fink +3 more
core
How effective is the invisible hand? Agricultural and food markets in Central and Eastern Europe [PDF]
, 2005 This volume of proceedings, available both as hard copy and pdf , is a compilation of selected contributions to the IAMO Forum 2005, which will be held in Halle (Saale), Germany, at the Institute of Agricultural Development in Central and Eastern Europe ...
Hockmann, Heinrich, Brosig, Stephan
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
"Great expectations - The regional administrative reform in Eastern Central Europe in anticipation of the EU" [PDF]
, 2000 [Introduction]. One of the key issues of governance of European Union is relationship between its governance and its boundaries in broad sense adopted by Friis and Murphy, who distinguish (after Smith 1996) four types of EU boundary; geopolitical ...
Majcherkiewicz, Tatiana.
core
Employment Recovery in Europe and Central Asia
, 2011 Despite high unemployment in most Eastern Europe and Central Asia (ECA) countries, people have not withdrawn from the labor market but continue to actively look for jobs. Unemployment increased significantly in ECA
Santos, Indhira +2 more
core +1 more source