Results 101 to 110 of about 7,350,988 (308)
A graph theoretic analysis of leverage centrality
AKCE International Journal of Graphs and Combinatorics, 2017 13 ...
Roger Vargas Jr. +4 more
openaire +3 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Graph Drawing Techniques for Geographic Visualization [PDF]
, 2004 Geovisualizers often need to represent data that consists of items related together. Such data sets can be abstracted to a mathematical structure, the graph.
Rodgers, Peter
core
Tripotent Divisor Graph of a Commutative Ring
International Journal of Mathematics and Mathematical SciencesIn this work, we introduce a new concept called the tripotent divisor graph of a commutative ring. It is defined with vertices set in a ring R, where distinct vertices r1 and r2 are connected by an edge if their product belongs to the set of all nonunite
Luma A. Khaleel +2 more
doaj +1 more source
Fusing Textual and Structural Information for Knowledge Graph Completion [PDF]
Jisuanji kexue yu tansuoKnowledge graph completion aims to infer missing and erroneous content in the knowledge graph based on existing information and external data, and to build a more complete and accurate knowledge graph.
ZANG Jie, REN Saisai, LU Rui, LU Shan, LIU Mengmeng, WANG Hao
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Bond Graph Based Stability Analysis of a Railway Traction System [PDF]
, 2005 This paper emphasises the interest of the Bond Graph approach for analysis and system design of heterogeneous and multi-field devices. In particular, the local stability analysis of non linear systems can be directly derived from the linearised Causal ...
Sareni, Bruno +3 more
core
On centrally symmetric graphs [PDF]
Mathematica Bohemica, 1996 If \(L\) is a finite graded lattice with \(n\) atoms such that its dual lattice \(L^\star\) is strong and if its covering graph is centrally symmetric, then \(L\) is isomorphic to \(2^n\). This result is proved using a similar result of B. Zelinka which holds for a finite modular lattice with \(n\) atoms.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source