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2015
Central Hypothyrodism (CeH) is the hypothyroid condition due to an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. CeH is about 1,000-fold more rare than primary hypothyroidism and raises several challenges for the clinicians, mainly because they cannot rely on the systematic use of the “reflex TSH strategy” for ...
L. Persani, M. Bonomi
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Central Hypothyrodism (CeH) is the hypothyroid condition due to an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. CeH is about 1,000-fold more rare than primary hypothyroidism and raises several challenges for the clinicians, mainly because they cannot rely on the systematic use of the “reflex TSH strategy” for ...
L. Persani, M. Bonomi
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Central Hypothyroidism and Its Role for Cardiovascular Risk Factors in Hypopituitary Patients
Endocrine, 2016 Hypothyroidism is characterized by hypometabolism, and may be seen as a part of secondary failure due to pituitary insufficiency or tertiary due to hypothalamic disease.
Ulla Feldt-Rasmussen, Marianne Klose
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Endocrinology and Metabolism Clinics of North America, 1992
Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary ...
M H, Samuels, E C, Ridgway
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Central hypothyroidism is an uncommon condition characterized by insufficient thyroid gland stimulation by TSH, owing to hypothalamic and/or pituitary dysfunction. It is rarely isolated but more often occurs in conjunction with deficiencies of other pituitary hormones, as well as with neurologic symptoms and signs owing to hypothalamic/pituitary ...
M H, Samuels, E C, Ridgway
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Southern Medical Journal, 2003
Central hypothyroidism is an exceedingly rare form of hypothyroidism that results from a variety of conditions affecting the hypothalamus and the pituitary gland. The classic biochemical abnormality seen in these patients includes a low serum level of circulating thyroxine (T4) concomitant with an inappropriately low level of thyrotropin.
Shehzad, Basaria +2 more
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Central hypothyroidism is an exceedingly rare form of hypothyroidism that results from a variety of conditions affecting the hypothalamus and the pituitary gland. The classic biochemical abnormality seen in these patients includes a low serum level of circulating thyroxine (T4) concomitant with an inappropriately low level of thyrotropin.
Shehzad, Basaria +2 more
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Central Hypothyroidism in Children
2014Central congenital hypothyroidism (CCH) is an underdiagnosed disorder poorly described in childhood and adolescence. Congenital defects in thyroid-stimulating hormone (TSH) synthesis, secretion or bioactivity may lead to a state of 'regulatory' hypothyroidism expressed through aberrantly low or normal TSH levels and low thyroxine (T4), a hormonal ...
Marta, García +2 more
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Central Hypothyroidism — A Neglected Thyroid Disorder
Nature Reviews Endocrinology, 2017Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both.
Giulia Rodari +2 more
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Central Hypothyroidism and Hyperthyroidism
Medical Clinics of North America, 1985Thyroid function is maintained by tonic secretion of TSH by the pituitary. TSH secretion, in turn, is dependent on hypothalamic TRH production. Therefore, diseases of the hypothalamus and pituitary are frequently associated with TSH deficiency, producing central hypothyroidism.
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Functional central hypothyroidism in the elderly
Aging Clinical and Experimental Research, 2008Previous studies have shown that blood concentrations of free thyroxin and basal thyroid-stimulating hormone (TSH) decrease during adult life. Suggested mechanisms include reduced thyroid activity resulting from decreased serum TSH concentrations, impairment of peripheral 5'-deiodinase, and an increase in reverse 3,5,3'-triiodothyronine due to non ...
Maren A, Sell +5 more
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Central Sleep Apnea in Hypothyroidism
American Review of Respiratory Disease, 1983Abstract This is a report of a 45-yr-old male patient who developed central sleep apnea syndrome because of hypothyroidism. In response to L-thyroxine therapy, the patient became euthyroid, and the apneic phenomenon disappeared.
R P, Millman +3 more
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Central Hypothyroidism—Trophoprivic Hypothyroidism
1987The term central hypothyroidism refers to the development of thyroid failure secondary to loss of TSH drive. The thyroid gland, which is intrinsically normal, gradually fails to function, since it is deprived of its tropic stimulus (hypothyrotropic hypothyroidism).
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