Results 61 to 70 of about 409,627 (265)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Annals of Geophysics, 2016 On August 24, 2016, at 01:36 UTC a MW 6.0 earthquake struck an extensive area of the central Apennines (Italy). It was followed by a large aftershock (MW 5.3, August 24, 02:33 UTC) and about 20 earthquakes with magnitude greater than 4.0, located between
Giovanna Cultrera +27 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Monitoring of some species of colonial nesting Ardeidae at Lake Trasimeno (Central Italy).
Rivista Italiana di Ornitologia - Research in Ornithology, 2012 During 1993-2010 we have monitored at Lake Trasimeno the population of colonial nesting herons, with the exception of Ardea purpurea. Two distinct heronries have been found, placed 9 km away from each other and composed of the following species ...
Francesco Velatta +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Annals of Geophysics, 1996 During paleoseismological investigations on the seismogenic structure responsible for the 1915 earthquake in the Fucino Plain (Central Italy), some trenches were excavated at the intersection between Roman-age channels and a fault characterized by ...
P. Galli, F. Galadini
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Obesity and Skin Carotenoid Score in Children from Center–Southern Italian Regions
AntioxidantsChildhood obesity represents a public concern worldwide. Evidence indicates that fruits and vegetables (FV) consumed as part of the daily diet reduce the global burden of obesity.
Giuseppina Augimeri +7 more
doaj +1 more source
Problems of reliability in earthquake parameters determination from historicaI records
Annals of Geophysics, 1996 Earthquake parameters determination from macroseismic data is a procedure, the reliability of whose results can be impaired by many problems related to quality, number and distribution of data.
G. Monachesi, V. Castelli
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source