Results 121 to 130 of about 3,963,986 (357)

Centralization, Hierarchy and Management Control in Modern Corporate Groups

The world of new economy
Despite the lack of a clear definition of the term «corporate group» in Russian legislation, experts consider it important to use it, as it has become a widespread phenomenon. Moreover, Moreover, corporate groups are currently reinforcing hierarchical structures once again.
R. R. Vasikov, S. V. Yudina
openaire   +2 more sources

The fiscal framework and urban infrastructure finance in China [PDF]

China has experienced more than 25 years of extraordinary economic growth. Underlying this growth has been a decentralized fiscal system, in which provinces and large cities are given the freedom to make infrastructure investmentsto stimulate local ...
Ming Su, Quanhou Zhao
core  

Modelling process knowledge in architectural design: A case-based approach [PDF]

, 1995
The paper presents on-going research aimed at the understanding and support of process knowledge in architectural design, from early and not sufficiently defined, to satisfactorily-defined phases.
Arlati, Ezio, Bottelli, Valeria, Fogh, Christian, Tirassa, Maurizio   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Digitally Enabled Generalist-Specialist Collaborative Care on Chronic Care Management of Community under the National Basic Public Health Service: Practical Exploration and Early Achievement [PDF]

Zhongguo quanke yixue
The advancement of high-quality national basic public health services continues to faces critical challenges, including insufficient quality resources in primary care and limited diagnostic and treatment capabilities. Since January 2022, Longhua District,
YAN Xinfeng, YU Chuanning, CAO Sijing, YIN Daogen, SHAN Xiaotao, WANG Yijing, XIE Pei, ZHAO Jie, YANG Weiyi, LIU Gang, HAN Xinxin
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Still a Problem Child : Central Management and Control after RITA [PDF]

Revenue Law Journal, 2005
The central management and control test for determining residency of a company has been problematic. The uncertainties in the test were addressed by Taxation Ruling TR 2004/15. The author believes the Ruling has done little to clarify the operation of the test.
openaire   +1 more source

Photovoltaic system criteria documents. Volume 1: Guidelines for evaluating the management and operations planning of photovoltaic applications [PDF]

Guidelines are provided to the Field Centers for organization, scheduling, project and cost control, and performance in the areas of project management and operations planning for Photovoltaics Test and Applications.
Billitti, Joseph W., Koenig, John C., Tallon, John M.   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source