Results 141 to 150 of about 3,963,986 (357)
Ecology and power in the periphery of Maasina : the case of the Hayre in the nineteenth century [PDF]
This article explores political tensions between successive nineteenth-century rulers of the inland delta of the Niger in central Mali (the Fulbe Diina of Hamdullahi and the Futanke successors of al-Hajj Umar) and the pastoral interests of the Fulbe ...
Bruijn, M., de, Dijk, H., van
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
State ownership - a residual role? [PDF]
The author reviews the state of thinking on the governance role of state ownership. He argues that a gradual transfer of operational control and financial claims over state assets remains the most desirable goal, but it needs to be paced to avoid ...
Perotti, Enrico
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
BMJ OpenObjective To evaluate the effectiveness of standardised antiretroviral therapy (ART) among different HIV subtypes in people living with HIV/AIDS (PLWHA), and to screen the best ART regimen for this patient population.Design A retrospective cohort study ...
Jing Li +10 more
doaj +1 more source
Fostering knowledge management in small and medium-sized enterprises [PDF]
, 2007 The submitted paper covers two topics which are essential for SMEs and their competitiveness: management control and knowledge management. On the basis of an empirical survey among producing SMEs in Central-Germany the authors investigated knowledge ...
Mittelstädt, Ewald +2 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Management Control and "Coherence" : Some Unresolved Questions [PDF]
Clothed in various formulations, the question of “coherence” is central to management control. Thus it is widely accepted that different forms of control “cannot be used effectively in every situation” (Merchant, 1998: 32, 69) – a statement referring to ...
Bourguignon , Annick +2 more
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FSC or Business as usual? Social impacts of forest certification in Cameroon [PDF]
, 2011 FSC or Business as usual? Social impacts of forest certification in Cameroon The paradigm of Sustainable Forest Management is central in the forestry laws enacted over the latest decades in the Congo Basin countries. However its implementation, and hence
Cerutti, Paolo Omar +2 more
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source