Results 121 to 130 of about 6,859,440 (291)

Moments of the generalized hyperbolic distribution [PDF]

In this paper we demonstrate a recursive method for obtaining the moments of the generalized hyperbolic distribution. The method is readily programmable for numerical evaluation of moments.
Scott, David J, Würtz, Diethelm, Tran, Thanh Tam, Dong, Christine   +3 more
core  

Central bank FOREX interentions assessed using realized moments

, 2009
This paper assesses the impact of G3 official central bank interventions on daily realized moments of DEM/USD exchange rate returns obtained from intraday data, 1989–2001. Event studies of the realized moments for the intervention day, the days preceding
Beine, M., Laurent, Sébastien, Beine, Michel, Palm, F.C., Palm, Franz, Laurent, S.   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ultra high energy cosmic rays versus models of high energy hadronic interactions

European Physical Journal C: Particles and Fields
We evaluate the consistency of hadronic interaction models in the CORSIKA simulation package with publicly available fluorescence telescope data from the Pierre Auger Observatory.
Blaž Bortolato, Jernej F. Kamenik, Michele Tammaro   +2 more
doaj   +1 more source

A novel local contrast method based on third-order central moments for infrared small target detection

Frontiers in Physics
As local contrast mechanisms are extensively utilized in infrared small target detection. However, the performance of existing local contrast-based methods is often compromised in complex backgrounds.
Danyang Xu, Dongdong Pang, Shimiao Gou, Zhaoyu Liu, Zhihai Zhuo   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Large Deviations of Generalized Method of Moments and Empirical  Likelihood Estimators [PDF]

This paper studies large deviation properties of the generalized method of moments and generalized empirical likelihood estimators for moment restriction models.
Taisuke Otsu
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Moments of IV and JIVE Estimators [PDF]

We develop a new method, based on the use of polar coordinates, to investigate the existence of moments for instrumental variables and related estimators in the linear regression model. For generalized IV estimators, we obtain familiar results. For JIVE,
Russell Davidson, James G. MacKinnon
core