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Muscle Relaxant Action of MS-322, a New Centrally Acting Muscle Relaxant, in Rats

General Pharmacology: The Vascular System, 1998
1. The pharmacological properties of (R)-(+)-3-phenyl-5-¿2-(1-pyrrolidinylmethyl)-butyryl¿isoxazole hydrochloride (MS-322) were investigated and compared with those of other muscle relaxants. 2. MS-322 (3-12 mg/kg, IV) reduced spinal reflex potentials in acutely spinalized rats dose dependently.
T, Otsu, T, Nagao, H, Ono
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Cyclobenzaprine: A novel centrally acting skeletal muscle relaxant

Neuropharmacology, 1975
Abstract The muscle relaxant activity of cyclobenzaprine relative to chlorpromazine and diazepam in several animal models manifesting hypertonic skeletal muscle activity is described. In mice subjected to electrical and chemical induced tonic-extensor seizures, only cyclobenzaprine achieved a protective index greater than unity in all preparations ...
N N, Share, C S, McFarlane
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Centrally acting oral skeletal muscle relaxants

American Journal of Health-System Pharmacy, 1980
A critical examination of the literature on centrally acting, orally administered skeletal muscle relaxants (SMRs) is presented. The available comparative clinical studies are reviewed, and the pharmacology, metabolism and adverse effects of the oral SMRs are discussed briefly. The drugs covered are carisoprodol, chlorphenesin carbamate, chlorzoxazone,
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Pharmacological properties of NK433, a new centrally acting muscle relaxant

European Journal of Pharmacology, 1995
The pharmacological properties of NK433 ((-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone+ ++ monohydrochloride), a novel muscle relaxant, were investigated. NK433 inhibited intercollicular decerebrate rigidity (gamma-rigidity) and anemic decerebrate rigidity (alpha-rigidity) dose dependently.
K, Sakitama   +4 more
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