Results 211 to 220 of about 10,023 (257)
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Central Nervous System Effects of Intrathecal Muscle Relaxants in Rats
Anesthesia & Analgesia, 1993When given for a sufficient time and dose intravenously, neuromuscular blocking drugs eventually can enter the cerebrospinal fluid (CSF). To study the potential pharmacologic consequences of neuromuscular blocking drugs in the CSF, a model was developed in the rat by using an intrathecal infusion of these drugs.
J, Szenohradszky +6 more
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Differential sensitivity of the flexor reflex to centrally acting muscle relaxants
Toxicology and Applied Pharmacology, 1960Abstract Mephenesin, methocarbamol, styramate, and chlorzoxazone are alike in their ability to depress the flexor reflex of the intact chloralose-urethane-anesthetized cat at doses that leave the patellar reflex unchanged.
L B, WITKIN, P, SPITALETTA
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Effects of tizanidine, a centrally acting muscle relaxant, on motor systems
General Pharmacology: The Vascular System, 1986Effects of tizanidine were studied with special reference to the effect on motor systems. The drug effectively reduced the intercollicular decerebrate rigidity and gamma-activity indirectly recorded from muscle spindle afferent discharges without showing the direct inhibitory effect on muscle spindles in rats.
H, Ono +8 more
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Biofeedback and Self-Regulation, 1980
The relationship of "awareness of muscle tension" to depth of relaxation was explored. In one experiment, accuracy of forearm flexor control was assessed using the psychophysical method of magnitude production, and depth of flexor relaxation was measured using the integrated EMG before and after EMG biofeedback training.
D W, Stilson, I, Matus, G, Ball
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The relationship of "awareness of muscle tension" to depth of relaxation was explored. In one experiment, accuracy of forearm flexor control was assessed using the psychophysical method of magnitude production, and depth of flexor relaxation was measured using the integrated EMG before and after EMG biofeedback training.
D W, Stilson, I, Matus, G, Ball
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Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant
Equine Veterinary Journal, 1970Summary A review of the history of centrally‐acting muscle relaxants has been given. The centrally‐acting muscle relaxant glyceryl guaiacolate has been used extensively in continental Europe and, within recent years, has attracted the attention of North American workers.
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Effects of NK433, a new centrally acting muscle relaxant, on masticatory muscle reflexes in rats
European Journal of Pharmacology, 1996The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic periodontal masseteric reflex.
Y, Ozawa +3 more
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Involvement of imidazoline receptors in the centrally acting muscle-relaxant effects of tizanidine
European Journal of Pharmacology, 2002The centrally acting muscle relaxant tizanidine has an imidazoline structure and binds not only to alpha(2)-adrenoceptors but also to imidazoline receptors. The role of imidazoline receptors in the muscle-relaxant effect of tizanidine was studied using the alpha(2)-adrenoceptor/imidazoline receptor antagonist idazoxan and the alpha(2)-adrenoceptor ...
Motoko, Honda +3 more
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[Cleavage and biotransformation of the central muscle relaxant chlormezanone].
Die Pharmazie, 1998Chlormezanone, a chiral centrally acting muscle relaxant, will be cleaved at its S-C-1 bond by an autoprotolytic process. The optimum of chemical stability exists between pH 2 up to pH 9 with a maximum at pH 7.4. The plasma half life at 37 degrees C is 76 h.
H, Oelschläger +8 more
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Combination of central and peripheral muscle relaxants in the treatment of post-stroke spasticity
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019To study the electromiographic (EMG) parameters and to evaluate the therapeutic efficacy of a combination of central (baclofen, baclosan) and peripheral (incobotulotoxinA, xeomin) muscle relaxants in the treatment of post-stroke spasticity (PSS).Ninety-six patients with PSS of upper and lower limbs were divided into 2 groups: the first group (n=56) was
D A, Iskra +3 more
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