Results 71 to 80 of about 1,317,105 (347)

An Interesting Case Of Acute Disseminated Encephalomyelitis [PDF]

, 2008
Acute disseminated encephalomyelitis (ADEM) is an uncommon inflammatory demyelinating disease of the central nervous system. The disease typically occurs after infections or vaccinations.
Kumar, Satish, Raina, Rajiv, Sharma, Ashok, Sharma, Mohit   +3 more
core  

The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis [PDF]

, 2018
Lyme borreliosis (LB) is the most common tick-borne disease caused by the spirochete Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia, respectively.
Bordignon, Valentina, Cavallo, Ilaria, D'Agosto, Giovanna, Di Domenico, Enea Gino, Ensoli, Fabrizio, Gallo, Maria Teresa, Pimpinelli, Fulvia, Pontone, Martina, Prignano, Grazia, Toma, Luigi, Trento, Elisabetta   +10 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Efficacy and safety of compound porcine cerebroside and ganglioside injection (CPCGI) versus piracetam on cognition and functional outcomes for adults with traumatic brain injury: A study protocol for randomized controlled trial

Heliyon
Background: Traumatic brain injury (TBI) is a common neurosurgical disease in emergency rooms with poor prognosis, imposing severe burdens on patients and their families.
Tao Liu, Yunhu Yu, Liang Mi, Zhihao Zhao, Mingqi Liu, Jiao Wang, Xin Wang, Zhuang Sha, Meng Nie, Weiwei Jiang, Chenrui Wu, Jiangyuan Yuan, Chuanxiang Lv, Biao Zhao, Kun Lin, Zhanying Li, Zhenyu Luo, Xuanhui Liu, Yu Qian, Rongcai Jiang   +19 more
doaj   +1 more source

Central nervous system Cryptococcoma mimicking demyelinating disease: a case report

BMC Neurology, 2020
Background Cerebral cryptococcomas is a rare form of central nervous system cryptococcosis. Most previous cases were mistaken for neoplasm before surgery.
Jie Wei, Xiang-Yu Li, Yue Zhang
doaj   +1 more source

Viral diseases of the central nervous system [PDF]

Current Opinion in Virology, 2015
Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system.
Phillip A, Swanson, Dorian B, McGavern
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]

, 2017
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached, Fish, Lisa, Goodarzi, Hani, Najafabadi, Hamed S   +3 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Alpha- synuclein immunoreactivity in the enteric nervous system of human small intestine [PDF]

, 2018
Alpha-synuclein (α-syn) is a 140 amino acid protein, belonging to the synuclein family, expressed in mammalian neurons. Structural alterations of α-syn as well as its overexpression have been related to the onset and the progression of several human ...
Casini, Arianna, Chirletti, Piero, Vaccaro, Rosa   +2 more
core