Results 91 to 100 of about 7,903,711 (288)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Two conserved vocal central pattern generators broadly tuned for fast and slow rates generate species-specific vocalizations in Xenopus clawed frogs. [PDF]

Elife, 2023
Yamaguchi A, Peltier M.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

NEURONpyxl: fast, flexible, Python-integrated simulation of biophysical neural networks with complex plastic synapses

Frontiers in Computational Neuroscience
IntroductionNEURON has been widely used as an empirically-based simulation tool, especially for multi-compartment conductance-based neuronal modeling. The network mediating feeding in Aplysia californica has been extensively studied as a model central ...
Uri Dickman, Uri Dickman, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas, Hillel J. Chiel, Hillel J. Chiel, Hillel J. Chiel, John H. Byrne, Curtis L. Neveu   +11 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Rethinking Central Pattern Generators: A General Approach 1

, 2008
Central pattern generators (CPGs) have traditionally been modeled as sets of coupled bistable oscillators [2]. We present a framework for constructing models which avoid the shortcomings of these traditional models, while remaining biologically plausible.
Charles H. Anderson B, Chris Eliasmith A
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Supplemental Material, Title_and_description_for_supplemental_materials - Three-dimensional walking of a simulated muscle-driven quadruped robot with neuromorphic two-level central pattern generators

, 2019
Supplemental Material, Title_and_description_for_supplemental_materials for Three-dimensional walking of a simulated muscle-driven quadruped robot with neuromorphic two-level central pattern generators by Yasushi Habu, Keiichiro Uta and Yasuhiro Fukuoka ...
Keiichiro Uta (7894553), Yasushi Habu (7894550), Yasuhiro Fukuoka (7894556)   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source