Results 141 to 150 of about 7,903,711 (288)

Implementing and Documenting Random Number Generators [PDF]

open access: yes
As simulation arid Monte Carlo continue to play an increasing role in statistical research, careful attention must be given to problems which arise in implementing and documenting collect ions of random number generators. This paper examines the value of
David C. Hoaglin
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Homecoming parade; Alpha Phi Alpha carrying banner "Happy Birthday Alpha Phi Alpha 50yrs"; marching band playing behind

open access: yes
In a Central Methodist University (formerly Central College) homecoming parade, Alpha Phi Alpha members carry a banner reading "Happy Birthday Alpha Phi Alpha 50yrs". A marching band follows the sorority.
Central Methodist University, Smiley Memorial Library
core  

Neurythmic: A Rhythm Creation Tool Based on Central Pattern Generators

open access: yes, 2018
We describe the development of Neurythmic: an interactivesystem for the creation and performance of fluid, expressivemusical rhythms using Central Pattern Generators(CPGs). CPGs are neural networks which generate adaptive rhythmic signals.
Bennett, Daniel
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Effect of Treadmill Training Protocols on Locomotion Recovery in Spinalized Rats

open access: yesJournal of Medical Signals and Sensors, 2017
Both treadmill training and epidural stimulation can help to reactivate the central pattern generator (CPG) in the spinal cord after a spinal cord injury.
Hamid R Kobravi   +2 more
doaj  

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