Results 51 to 60 of about 717,787 (268)

System of public administration bodies of environmental protection in Ukraine and possibility of its adaptation to european requirements

open access: yesAspekti Publìčnogo Upravlìnnâ, 2014
Analyzed the system of system of public administration bodies of environmental protection in Ukraine, special attention is paid to lighting problems the Ministry of Ecology and Natural Resources of Ukraine, given the powers of other government bodies to ...
L. L. Prokopenko, N. L. Tishkova
doaj  

REGIONAL LEADERS OF THE COMMUNIST PARTY OF THE SOVIET UNION AND THEIR IDEAS ON ECONOMIC MANAGEMENT IMPROVEMENT IN 1965–1985, SIBERIA

open access: yesВестник Кемеровского государственного университета, 2018
The study defines the positions of the first secretaries of the Siberian regional committees of the Communist Party of the Soviet Union (CPSU) in the field of economic management in 1965 – 1985.
A. B. Konovalov
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Global public policy, transnational policy communities, and their networks [PDF]

open access: yes, 2008
Public policy has been a prisoner of the word "state." Yet, the state is reconfigured by globalization. Through "global public–private partnerships" and "transnational executive networks," new forms of authority are emerging through global and regional ...
Albert M.   +35 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

THE CONTROL OVER LOCAL PUBLIC FINANCES IN ROMANIA AND IN OTHER RELEVANT COUNTRIES OF EU [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
Local public finances are an essential component of public finances together with the public finances of the central state administration. Because, besides the right of local representative bodies to decide on issues of local interest, local autonomy ...
NICU MARCU , RALUCA ANTONEAC
doaj  

Basic problems of management in the sphere of forest relations in retrospect of public prosecutor [PDF]

open access: yesСибирский лесной журнал, 2016
Public administration of forests is one of the most important sectors of ecological public administration at the national and local levels. Forest legislation is the legal basis for management, whose quality and regulatory capacity ensure the ...
I. A. Kuzmin
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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