Results 111 to 120 of about 345,428 (274)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

ERRATUM: Prevalence and Determinants of Metabolic Syndrome in Young Adults — Insights from a Jordanian Medical Student Cohort

Clinical Diabetology
OBJECTIVE: Metabolic syndrome (MetS), characterized by central obesity, hypertension, dyslipidemia, and high blood sugar levels, increases the risk of cardiovascular disease and type 2 diabetes.
Nesreen A Saadeh, Sakhr Alshwayyat, Omran A. Abu-Dhaim, Karam I. Khraim, Khaled O. Draghmeh, Joan F. Fallouh, Waleed Y. Hijazi, Daoud O. Al Aruri, Abdel-Latif Z. Mughrabi Sabbagh, Mohammad R. Alkhaldi, Ahmad T. Haimour   +10 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Prevalence and Determinants of Metabolic Syndrome in Young Adults — Insights from a Jordanian Medical Student Cohort

Clinical Diabetology
OBJECTIVE: Metabolic syndrome (MetS), characterized by central obesity, hypertension, dyslipidemia, and high blood sugar levels, increases the risk of cardiovascular disease and type 2 diabetes.
Nesreen A Saadeh, Sakhr Alshwayyat, Omran A. Abu-Dhaim, Karam I. Khraim, Khaled O. Draghmeh, Joan F. Fallouh, Waleed Y. Hijazi, Daoud O. Al Aruri, Abdel-Latif Z. Mughrabi Sabbagh, Mohammad R. Alkhaldi, Ahmad T. Haimour   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Development and preliminary evaluation of a short self-report measure of generalized pain hypersensitivity

Journal of Pain Research, 2019
Peter F van Bemmel,1 Martijn AH Oude Voshaar,2 Peter M ten Klooster,2 Harald E Vonkeman,1,2 Mart AFJ van de Laar1,2 1Department of Rheumatology, Medisch Spectrum Twente, Enschede, Netherlands; 2Department of Psychology, Health, and Technology, University
van Bemmel PF, Oude Voshaar MAH, ten Klooster PM, Vonkeman HE, van de Laar MAFJ   +4 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Massive MIMO for Ultra-reliable Communications with Constellations for Dual Coherent-noncoherent Detection

, 2018
The stringent requirements of ultra-reliable low-latency communications (URLLC) require rethinking of the physical layer transmission techniques. Massive antenna arrays are seen as an enabler of the emerging $5^\text{th}$ generation systems, due to ...
Angjelichinoski, Marko, Bana, Alexandru-Sabin, de Carvalho, Elisabeth, Popovski, Petar   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Theory of Robot Communication: II. Befriending a Robot over Time

, 2018
In building on theories of Computer-Mediated Communication (CMC), Human-Robot Interaction, and Media Psychology (i.e. Theory of Affective Bonding), the current paper proposes an explanation of how over time, people experience the mediated or simulated ...
Hoorn, Johan F.
core