Results 41 to 50 of about 6,129,726 (293)

Dysfunction of inhibitory interneurons contributes to synaptic plasticity via GABABR-pNR2B signaling in a chronic migraine rat model

Frontiers in Molecular Neuroscience, 2023
BackgroundAccording to our previous study, the loss of inhibitory interneuron function contributes to central sensitization in chronic migraine (CM). Synaptic plasticity is a vital basis for the occurrence of central sensitization.
Xiaoxu Zeng, Xiaoxu Zeng, Yingying Niu, Guangcheng Qin, Dunke Zhang, Lixue Chen   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Central sensitization in CRPS patients with widespread pain: A cross-sectional study. [PDF]

, 2023
OBJECTIVE Widespread pain hypersensitivity and enhanced temporal summation of pain (TSP) are commonly reported in patients with complex regional pain syndrome (CRPS) and discussed as proxies for central sensitization.
Schweinhardt, Petra, Hubli, Michèle, Scheuren, Paulina Simonne, Mollo, Anna, Iara De Schoenmacker, Paulina Simonne Scheuren, Rosner, Jan, Laura Sirucek, Florian Brunner, Petra Schweinhardt, Armin Curt, De Schoenmacker, Iara, Curt, Armin, Anna Mollo, Michèle Hubli, Sirucek, Laura, Jan Rosner, Brunner, Florian   +17 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village

Journal of Pain Research, 2021
Koji Akeda, Norihiko Takegami, Junichi Yamada, Tatsuhiko Fujiwara, Akinobu Nishimura, Akihiro Sudo Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, JapanCorrespondence: Koji AkedaDepartment of Orthopaedic Surgery, Mie ...
Akeda K, Takegami N, Yamada J, Fujiwara T, Nishimura A, Sudo A   +5 more
doaj  

Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model

The Journal of Headache and Pain, 2023
Background Central sensitization has been widely accepted as an underlying pathophysiological mechanism of chronic migraine (CM), activation of cannabinoid type-1 receptor (CB1R) exerts antinociceptive effects by relieving central sensitization in many ...
Xiaoxu Zeng, Jia Mai, Hongjian Xie, Ling Yang, Xiaojuan Liu   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Pain sensitization in hand osteoarthritis

, 2021
Pain sensitization, i.e. increased pain sensitivity, contribute to chronic pain in many conditions. This thesis examined the relevance of peripheral and central pain sensitization in persons with hand osteoarthritis (OA).
Pettersen, Pernille Steen
core   +1 more source

Chronic Overlapping Pain and Central Sensitization in Chronic Pelvic Pain: Do Positive and Negative Affect Play a Role?

Pain Research and Management
Chronic pelvic pain (CPP) has a complex etiology and a high degree of coprevalence with other chronic overlapping pain conditions (COPCs). Evidence suggests that central sensitization contributes to these conditions; however, the psychological risk and ...
Shreela Palit, Meryl J. Alappattu, Jenna M. Wilson, Jessica S. Heft, Emily J. Bartley   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source