Results 41 to 50 of about 6,588,200 (233)

Cross-cultural adaptation and validation of the Finnish version of the central sensitization inventory and its relationship with dizziness and postural control

BMC Neurology, 2021
Background Central Sensitization (CS) involves dysfunction in neurophysiological mechanisms that increase neuronal responses to both noxious and non-noxious stimuli in the central nervous system.
Jani Mikkonen, Hannu Luomajoki, Olavi Airaksinen, Randy Neblett, Tuomas Selander, Ville Leinonen   +5 more
doaj   +1 more source

Association between the central sensitization inventory score and health-related quality of life in community-dwelling middle-aged and older adults.

PLoS ONE
BackgroundCentral sensitization is an important factor associated with impaired health-related quality of life in patients with musculoskeletal disorders and community-dwelling older adults.
Naoki Segi, Hiroaki Nakashima, Ryotaro Oishi, Sadayuki Ito, Jun Ouchida, Ippei Yamauchi, Yasuhiro Nagatani, Taisuke Seki, Yasuhiko Takegami, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama   +11 more
doaj   +1 more source

The Value of High-Frequency Repetitive Transcranial Magnetic Stimulation of the Motor Cortex to Treat Central Pain Sensitization Associated With Knee Osteoarthritis

Frontiers in Neuroscience, 2019
AimChronic pain associated with knee osteoarthritis may develop in connection with a maladaptive process of pain sensitization in the central nervous system.
Jean-Paul Nguyen, Véronique Dixneuf, Julien Esnaut, Alcira Suarez Moreno, Catherine Malineau, Julien Nizard, Jean-Pascal Lefaucheur   +6 more
doaj   +1 more source

POS1450 PSYCHOMETRIC PROPERTIES OF THE CENTRAL SENSITIZATION INVENTORY IN PATIENT WITH FIBROMYALGIA

Annals of the Rheumatic Diseases, 2022
AbstractObjectiveThe goal of this study was to explore additional evidence of convergent and discriminant validity of the Central Sensitization Inventory (CSI) in a large sample of subjects with fibromyalgia (FM).MethodsPatients were consecutively enrolled for a cross‐sectional assessment comprehensive of three FM‐specific measures (the revised ...
F. Salaffi, S. Farah, C. Mariani, P. Sarzi-Puttini, M. Di Carlo   +4 more
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A preliminary study of the child abuse and central sensitization in adolescent patients with chronic non-organic chest pain and an overlooked condition: juvenile fibromyalgia syndrome

Pediatric Rheumatology Online Journal, 2020
Background Only a small percentage of pediatric chest pain is of cardiac origin and the most common detected cause is musculoskeletal. Among musculoskeletal causes, acute chest pain is better described, with the causes of chronic pain not being ...
Basak Mansiz-Kaplan, F. Figen Ayhan, Mihriban Cagli, Fatih Atik, İbrahim Ece   +4 more
doaj   +1 more source

The Dutch Central Sensitization Inventory (CSI) [PDF]

The Clinical Journal of Pain, 2016
Objectives: A standardized assessment of central sensitization can be performed with the Central Sensitization Inventory (CSI), an English questionnaire consisting of 25 items relating to current health symptoms. The aim of this study was to translate the CSI into Dutch, to perform a factor analysis to reveal the underlying ...
Kregel, Jeroen, Vuijk, Pieter J, Descheemaeker, Filip, Keizer, Doeke, van der Noord, Robert, Nijs, Jo, Cagnie, Barbara, Meeus, Mira, Van Wilgen, Paul   +8 more
openaire   +4 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Additional file 3 of Cross-cultural adaptation and validation of the German Central Sensitization Inventory (CSI-GE)

, 2021
Additional file 3: Supplement 3.
Steffen Ehrhardt (11294832), Frank Petzke (797347), Andreas Leha (7548410), Marjan Laekeman (11294829), Randy Neblett (5782670), Angela Dieterich (5946134), Michel Klute (11294826), Joachim Ulma (11294835), Axel Schäfer (5365960), Katrin Kuss (11030853)   +9 more
core   +1 more source

Gradient‐Conductivity Architecture Enables Synchronous Enhancement of Sensitivity and Detection Range in Multifunctional All‐Paper Sensors

Advanced Functional Materials, EarlyView.
A gradient‐engineered all‐paper sensor is fabricated by integrating MXene and in situ grown AgNPs within hierarchical cellulose networks. The device breaks the sensitivity–detection range trade‐off through cascaded conductive pathways, enabling ultrahigh pressure sensitivity, humidity–pressure decoupled dual‐mode sensing, and outstanding EMI shielding,
Ao Li, Jun Xu, Dezhong Xu, Zhaohui Zhang, Jiyi Li, Daxian Cao, Kefu Chen, Mizi Fan   +7 more
wiley   +1 more source