Results 61 to 70 of about 6,588,200 (233)

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Central sensitization in women with endometriosis: a cross-sectional study

BMC Women's Health
Background Pain is the primary symptom of endometriosis and may progress into a chronic, acyclic condition driven by neuroinflammatory mechanisms, leading to neuropathic and ultimately nociplastic pain.
Anna Biasioli, Francesca Previtera, Ilaria Mazzera, Matilde Degano, Silvia Zermano, Veronica Tius, Ilaria Piacenti, Renato Seracchioli, Diego Raimondo, Monica Della Martina, Martina Arcieri, Stefano Restaino, Lorenza Driul, Giuseppe Vizzielli   +13 more
doaj   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Alexithymia and psychosomatic diseases in adolescents: primary headaches

Acta Biomedica Scientifica, 2023
Background. Alexithymia is traditionally regarded as a factor which influences the development of psychosomatic diseases and contribute to a more severe and prolonged course of somatic diseases the high level of alexithymia indicates the deficit in ...
E. A. Gorobets, O. R. Esin
doaj   +1 more source

Validation of the Japanese version of the Central Sensitization Inventory in patients with musculoskeletal disorders

PLOS ONE, 2017
Many musculoskeletal pain conditions are characterized by hypersensitivity, which is induced by central sensitization (CS). A questionnaire, the Central Sensitization Inventory (CSI), was recently developed to help clinicians identify patients whose presenting symptoms may be related to central sensitivity syndrome (CSS).
Katsuyoshi Tanaka, Tomohiko Nishigami, Akira Mibu, Masahiro Manfuku, Satoko Yono, Yoshikazu Shinohara, Akihito Tanabe, Rei Ono   +7 more
openaire   +3 more sources

Sensitization to common ragweed in Southern Bavaria: clinical and geographical risk factors in atopic patients [PDF]

, 2012
Background: Sensitization to common ragweed (Ambrosia artemisiifolia) is associated with a variety of risk factors, which are incompletely defined. Our aim was to evaluate the association of a variety of clinical, geographical and demographical variables
Sabanés Bové, Daniel, Herzinger, Thomas, Gmeiner, Jennifer, Küchenhoff, Helmut, Sabanés-Bové, Daniel, Walker, Annett, Kramer, Matthias, Ruëff, Franziska, Przybilla, Bernhard   +8 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

CENTRAL SENSITIZATION IN RHEUMATOID ARTHRITIS. A CROSS-SECTIONAL ANALYTIC STUDY

Central Asian Journal of Medical Hypotheses and Ethics
Aim: Here, we analyzed the relationship between central sensitization (CS) and neuropathic pain in disease activity in patients with Rheumatoid arthritis (RA).
Tuba Tülay Koca, Hasan Göğebakan, Gözde Çetin   +2 more
doaj   +1 more source

Cross-cultural adaptation and validity of the Italian version of the Central Sensitization Inventory

Musculoskeletal Science and Practice, 2018
Central sensitization (CS) is an important feature in patients with chronic pain. The Central Sensitization Inventory (CSI) was developed with the goal of detecting the patients' symptoms related to CS.This study aimed at cross-culturally adapting the CSI into Italian, and at assessing its structural and construct validity in patients with different ...
Chiarotto A, Viti C, Sulli A, Cutolo M, Testa M, Piscitelli D   +5 more
openaire   +5 more sources