Results 101 to 110 of about 1,090,342 (306)

Diagnosis of Isolated Central Vertigo: Report for a Series Cases

Risk Management and Healthcare Policy
Yong-Kun Ruan,1,2,* Wang-Kai He,1,* Qing-Qing Chen,1 Hua Hu3 1Department of Neurology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, 519020, People’s Republic of China; 2Faculty of Chinese Medicine, Macau ...
Ruan YK, He WK, Chen QQ, Hu H
doaj  

Challenges in diagnosis and management of central airway obstruction: Case series

SAGE Open Medical Case Reports
Central airway obstruction often presents with respiratory symptoms identical to those of common respiratory diseases. Diagnosis of central airway obstruction is challenging in clinical practice, especially misdiagnosed as asthma or chronic obstructive ...
Bao Le-Khac, Khoa Nguyen-Dang, Nam Vu-Hoai, Nam Nguyen-Thanh, Ngoc Duong-Minh, Thai-Hoa Tran-Ngoc, Lam Nguyen-Ho   +6 more
doaj   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease

Journal of Lipid Research, 2015
Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles that extend from generating the second messenger signaling lipid, phosphatidic acid, through hydrolysis of the membrane phospholipid, phosphatidylcholine, to ...
Rochelle K. Nelson, Michael A. Frohman
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Iodine Deficiency–Induced Goiter in Central New Jersey: A Case Series

AACE Clinical Case Reports, 2015
: Objective: We report 4 cases of iodine deficiency– induced goiter in minority women living in central New Jersey.Methods: Clinical presentations, laboratory data, thyroid 123I uptake, and thyroid sonograms were obtained from 4 minority women with ...
Amy Chow, MD, Xinjiang Cai, MD, PhD, Sophia Hu, MD, Xiangbing Wang, MD, PhD   +3 more
doaj  

Intraventricular antibiotics for severe central nervous system infections: a case series

Scientific Reports
Severe central nervous system infections (CNSI), including community-acquired CNSI (CA-CNSI) and healthcare-associated ventriculitis and meningitis (HAVM), present high morbidity and mortality. Intraventricular antibiotic treatment (IVT) is advisable for
Laura Arheilger, Massimo Barbagallo, Gaia Sofia Rancic, Federica Stretti, Sabeth Dietler-Ebner, Nicolas J. Mueller, Emanuela Keller, Claudio Togni, Giovanna Brandi   +8 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Primary central nervous system lymphoma: a series report and literature review

Discover Oncology
Objective This study aims to analyze the clinical features, Radiological findings and diagnostic characteristics (tissue biopsy, flow cytometry and cerebrospinal fluid cytology) of primary central nervous system lymphoma (PCNSL). To improve the diagnosis
Yueli Zou, Yaning Wu, Helin An, Mingzhao Song, Jingyi Zhang, Xiujun Yu, Yi Li   +6 more
doaj   +1 more source