Results 31 to 40 of about 35,590 (247)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Optimized loading effects on pressure steam sterilization of loaned surgical instruments using product family categorization

Scientific Reports
Wet packs of loaned surgical instruments have always been a challenge for the Central Sterile Supply Department. Compared to other factors affecting pressure steam sterilization, loading is full of variables in practice.
Zhan Meng, Yao Zhuoya, Geng Junhui, Li Manchun, Ding Lina   +4 more
doaj   +1 more source

Effects of four aluminum foil placement modes in testing cavitation effect of ultrasonic cleaning machine

Sterile Supply
ObjectiveThe present study intends to compare four aluminum foil placement modes in testing the cavitation effect of an ultrasonic cleaning machine so as to provide a reference for the operation in the central sterile supply department (CSSD).MethodsThe ...
Xiaoying Lai, Zhijuan Xu, Wei Zheng
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Design and Operation of Water Treatment System for Central Sterile Supply Department Based on Energy Conservation and Consumption Reduction

Sterile Supply
ObjectiveThe present study scientifically and reasonably designs a water treatment system for the central sterile supply department (CSSD) to achieve standardized water use, ensure the safety of instrument treatment, and reduce water resource waste ...
Yuanlian Zhao, Jie Yang, Anchan Zhou, Yue Xie   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Study on Routine Inspection Method for Flexible Intramedullary Reamer and Its Impact on Reducing Risk of Surgical Site Infection

Sterile Supply
ObjectiveTo explore the inspection methods for flexible intramedullary reamers (FIRs) to ensure cleaning quality and evaluate their potential value in reducing the risk of surgical site infection (SSI) in patients.MethodsFIRs are categorized into “wave ...
Wenru Huang, Xin Ju, Yunyu Jin, Pengjiao Niu   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The importance of paper records and their preservation period in a Central Sterile Supply Department: An experience from a oncology center in eastern India

Journal of Infection and Public Health, 2017
Everywhere recordkeeping is very essential for future need. This may be required for any audit purposes, legal issues and forgetting any incident. Record keeping is a specialized area in every hospital that is handled by specialized medical records ...
Debabrata Basu, Subhas C. Bag, Arijit Das, John D. Razario   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source