Results 51 to 60 of about 33,559 (247)

The effects of perfusion device technology in the cleaning of luminal instruments

Sterile Supply
ObjectiveTo observe the application effect of perfusion device technology in the cleaning of luminal instruments.MethodsA total of 400 of lumen surgical instruments received from the disinfection supply center of our hospital from April to October 2023 ...
Meifeng Cao, Chunxia Qian
doaj   +1 more source

Application of information tracing system-based five-in-one full-cycle management of precision surgical instruments (基于信息追溯系统的“五位一体”精密器械全周期管理模式应用)

中西医结合护理, 2023
Objective To evaluate the information tracing system-based five-in-one full-cycle management of precision surgical instruments. Methods A five-in-one full-cycle management of precision surgical instruments was established based on information tracing ...
XU Yuanle (许远乐), WANG Yuena (王岳娜), ZHU Kunkun (朱坤坤), REN Juanxia (任娟霞)   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Application of quality control circle activity in reducing the rate of defects in security management of medical oxygen supply system (降低医用供氧系统安全管理缺陷率的品管圈实践)

中西医结合护理, 2022
Objective To explore the value of quality control circle (QCC) activities in reducing the rate of defects in security management of medical oxygen supply system.
WANG Yuena (王岳娜), XU Yuanle (许远乐), REN Guqun (任顾群)   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Qualitative Study on Functional Quality Evaluation of Surgical Scissors Based on Different Stakeholder Perspectives

Sterile Supply
ObjectiveThe present study aims to deeply understand the functional maintenance and explore the criteria of surgical scissors in the central sterile supply department (CSSD) so as to evaluate the function of surgical scissors, and to provide basic data ...
Jun Peng, Rong Xu, Xiqiong Ding, Juan Zhu, Shiyu Yin, Si Chen, Lulu Huang   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Smart management of single surgical instruments through unique device identification (UDI) barcode tracking system for enhancing sterilization quality and patient safety

Antimicrobial Stewardship & Healthcare Epidemiology
Introduction: We propose to develop a Unique Device Identification (UDI) barcode tracking system for surgical instruments. This system aims to enhance hospital processes, thereby benefiting both patients and staff members.
Jr-Huei Liu, Chu-Ying Wu, Wei-Ting Liang, Min-Fen Hsu, Chiu-Yu Liu   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source