Results 111 to 120 of about 194,778 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Research integrity and data ethics in AI-driven integrated healthcare: a critical appraisal

Frontiers in Public Health
The convergence of artificial intelligence (AI) and healthcare is reshaping clinical practice, yet this transformation raises pressing questions about scientific rigor and ethical responsibility.
Wei Zeng, Hong Wei, Yongkai Chen, Jing Tang, Jingyi Ge, Huilong Chen   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Improving precision instrument cleaning with a quality control module: implementation and outcomes

Frontiers in Public Health
ObjectiveTo evaluate the effectiveness of a cleaning quality control module integrated into a hospital’s Disinfection Supply Center (DSC) for improving the cleaning quality of precision surgical instruments.MethodsIn June 2023, a cleaning quality control
Juan Xiong, Juan Xiong, Wei Jiang, Wei Wan, Li Zuo, Ping Tu, Dong Xia Rao   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genome of a novel Fangshan bunya-like virus identified in mosquitoes from Shandong Province, China

Scientific Reports
Mosquitoes are important vectors of a wide range of viruses and serve as pivotal vectors with complex ecological functions that facilitate the transmission of these pathogens between hosts, such as humans, through biting behavior.
Yuli Zhang, Yujie Liu, Lin Liu, Yingxin Tu, Meixi Ren, Guoyu Niu, Hengyi Sun, Yujing Zhu   +7 more
doaj   +1 more source

Evaluating risks to supply chain sustainability in a KwaZulu-Natal hospital. [PDF]

, 2018
Masters Degree, University of KwaZulu-Natal, Durban.This study reports on an exploration of risks experienced in the field of supply chain management within the Republic of South African public sector with specific attention to the KwaZulu-Natal ...
Gwala, Mbalenhle Pretty.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hospital Central Sterile Supply Departments [PDF]

BMJ, 1960
openaire   +2 more sources

Organization of a central supply system for Nursing Units

, 1989
Ο εφοδιασμός των νοσοκομείων και στη συνέχεια των νοσηλευτικών μονάδων, πρέπει να γίνεται προσεκτικά. Να λαμβάνεται υπόμη ο οικονομικός παράγοντας αλλά και η καταλληλότητα και ποιότητα του υλικού, ώστε να επιτυγχάνεται η σωστή νοσηλεία των αρρώστων.
Παπαδημητρίου, Ε.
core   +1 more source