Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Reverse centrality queries in complex networks
, 2009 The increasing availability of complex network data from social networks and other sources provides new opportunities for exploration and analysis. In this thesis, we introduce the reverse centrality query, a novel query for complex networks. For a query node q, the reverse centrality query returns a locally maximal induced subgraph R, where q ?
openaire +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
[Governance, organization, and task distribution in family planning in Latin America and the CaribbeanGovernança, organização e distribuição de tarefas no planejamento familiar na América Latina e no Caribe]. [PDF]
Rev Panam Salud PublicaGómez Ponce de León R +5 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
[Cirrhotic cardiomyopathy – Clinically fact or academic curiosity? Review. Part 3: treatment] [PDF]
Rev Fac Cien Med Univ Nac CordobaRamos H, Altieri M.
europepmc +1 more source
[Knowledge of zoonoses transmission routes and of the species concerned among rural workers]. [PDF]
Rev Argent Microbiol, 2014 Molineri AI, Signorini ML, Tarabla HD.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Hibridación de energía fotovoltaica y baterías en una central hidroeléctrica reversible existente [PDF]
Este proyecto estudia la hibridación hidro-solar con almacenamiento en baterías como una alternativa para avanzar hacia un modelo energético más sostenible en España.
Ñáñez Macías, Didier Edinson +4 more
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