Escales mecàniques reversibles a la Baixada de la Glòria
El 5 de maig de 2024 entren en funcionament els primers trams d’escales mecàniques reversibles a la Baixada de la Glòria, al districte de ...
Gerència de Serveis Generals +3 more
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Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
[Stroke mimic after wasp sting in a child with Charcot-Marie-Tooth neuropathy X type 1]. [PDF]
An Sist Sanit NavarHernando Larroy A +3 more
europepmc +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
[Governance, organization, and task distribution in family planning in Latin America and the CaribbeanGovernança, organização e distribuição de tarefas no planejamento familiar na América Latina e no Caribe]. [PDF]
Rev Panam Salud PublicaGómez Ponce de León R +5 more
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
[Cirrhotic cardiomyopathy – Clinically fact or academic curiosity? Review. Part 3: treatment] [PDF]
Rev Fac Cien Med Univ Nac CordobaRamos H, Altieri M.
europepmc +1 more source
[Knowledge of zoonoses transmission routes and of the species concerned among rural workers]. [PDF]
Rev Argent Microbiol, 2014 Molineri AI, Signorini ML, Tarabla HD.
europepmc +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source