Results 21 to 30 of about 8,976 (287)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Semejanza entre el micro y el macrocosmo [PDF]

open access: yes, 2011
Ideas muy generales sobre las semejanzas entre el microcosmo y el macrocosmos , junto a una visión muy particular de las principales leyes de la naturalezaSe analizan las leyes que rigen el microcosmos y el macrocosmos y se llama la atención de su ...
Domínguez Alonso, Manuel
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

La energía en Extremadura [PDF]

open access: yes, 1983
En este estudio se trata de dar una definición de lo que se considera energía así como un rápido informe histórico. Se realiza una revisión de los diferentes tipos de energía, para luego tratar ampliamente las principales fuentes de energía existentes ...
Hernández González, Juan Manuel   +1 more
core  

Reversible central neural hyperexcitability: an electroencephalographic clue to hypocalcaemia [PDF]

open access: yesBMJ Case Reports, 2017
A 23-year-old male patient presented with cognitive decline and seizures. Examination revealed Chvostek's and Trousseau's signs. Investigations revealed hypocalcaemia, hyperphosphatemia and normal intact parathyroid hormone levels. Imaging showed calcifications in bilateral basal ganglia, thalamus and dentate nuclei.
Bhagyadhan A Patel   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Las conexiones matemáticas entre la derivada e integral: una revisión de la literatura educativa [PDF]

open access: yes, 2016
El presente escrito estudia a las conexiones matemáticas y a dos conceptos centrales del Cálculo: la derivada y la integral. Buscamos responder una pregunta central ¿Cuál es el estado actual de las investigaciones relacionadas con las conexiones ...
Dolores, Crisólogo   +1 more
core  

Ring endomorphisms satisfying the central reversible property

open access: yesProceedings - Mathematical Sciences, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Arnab Bhattacharjee   +1 more
openaire   +2 more sources

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance [PDF]

open access: yesDiabetes, 2005
Voluntary overfeeding rapidly induces resistance to the effects of systemic insulin and leptin on liver glucose metabolism. To examine whether central administration of recombinant leptin can restore leptin and insulin action on liver glucose fluxes, we infused leptin in the third cerebral ventricle of conscious overfed rats during pancreatic-insulin ...
Alessandro, Pocai   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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