Results 61 to 70 of about 8,976 (287)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

La revolución química : entre la historia y la memoria [PDF]

open access: yes, 2006
KIM, Mi Gyung. Affinity, that elusive dream : a genealogy of the chemical revolution. MILLER, David P. Discovering water : James Watt, Henry Cavendish and the nineteenth-century «water controversy». BERETTA, Marco (ed.). Lavoisier in perspective.
Bertomeu Sánchez, José Ramón
core  

La dialéctica en Proclo [PDF]

open access: yes, 2010
Análisis del concepto de dialéctica en Proclo, a partir de los libros II, V y VII del Comentario al Parménides. Se consideran tres aspectos: 1º) La dialéctica como método.2º) La dialéctica como perspectiva particular de la totalidad del universo. 3º) La
Garay Suárez-Llanos, Jesús Francisco De
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Possibilities and limitations of the intercultural education in mapuche context [PDF]

open access: yes, 2011
La educación intercultural en contexto mapuche, donde se exponen antecedentes teóricos y prácticos referidos a su origen en América Latina y Chile, asociado al carácter histórico, monocultural y centralizado de la educación. La educación intercultural es
Quintriqueo Millán, Segundo
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

El problema de la irreversibilidad: algunas precision conceptuales [PDF]

open access: yes, 2001
El objetivo del presente trabajo consiste en precisar los conceptos centrales involucrados en el problema de la irreversibilidad. En particular, se distinguirán los conceptos de t-invariancia y de reversibilidad, para luego señalar las relaciones entre ...
Lombardi, Olimpia
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Patrimonio de Colonia Hinojo [PDF]

open access: yes, 2003
Atendiendo a las actuales recomendaciones de abordar la cuestión patrimonial desde una óptica multidisciplinaria y de formular nuevas herramientas teórico-prácticas para la valorización, recuperación y ...
Traversa, Luis Pascual   +1 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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