Results 61 to 70 of about 40,893 (263)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Quantifying Node Influence in Networks: Isolating-Betweenness Centrality for Improved Ranking

IEEE Access
In complex networks, node impact refers to an individual node’s significance or influence within the structure. The evaluation of the impact of the nodes in information transmission, prevention of pandemics, and resilience applications of the ...
Mondikathi Chiranjeevi, V. Sateeshkrishna Dhuli, Murali Krishna Enduri, Koduru Hajarathaiah, Linga Reddy Cenkeramaddi   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

New centrality measure: ksi-centrality

CoRR
We introduce new centrality measures, called ksi-centrality and normalized ksi-centrality measure the importance of a node up to the importance of its neighbors. First, we show that normalized ksi-centrality can be rewritten in terms of the Laplacian matrix such that its expression is similar to the local clustering coefficient. After that we introduce
openaire   +3 more sources

To Be or Not to Be Central: On the Stability of Network Centrality Measures in Shakespeare's "Hamlet"

, 2020
Centrality measures derived from character networks can be used to detect the main characters in a play. For example, previous research has shown that characters with high network centrality typically perform the majority of speech acts and appear in most of the scenes. However, one can extract character networks from plays in various ways.
Klimashevskaia, Anastasia, Geiger, Bernhard C., Hagmüller, Martin, Helic, Denis, Fischer, Frank   +4 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Inflow and outflow centrality: novel centrality metrics inspired by graph convolution

Applied Network Science
Centrality metrics quantify a node’s importance within a network based on a node’s connectivity, path position, proximity to other nodes, or influence from neighbors.
Aram Papazian, Volkhard Helms
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source