Results 81 to 90 of about 43,402 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

New centrality measure: ksi-centrality

CoRR
We introduce new centrality measures, called ksi-centrality and normalized ksi-centrality measure the importance of a node up to the importance of its neighbors. First, we show that normalized ksi-centrality can be rewritten in terms of the Laplacian matrix such that its expression is similar to the local clustering coefficient. After that we introduce
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Social networks: Prestige, centrality, and influence (Invited paper) [PDF]

We deliver a short overview of di erent centrality measures and influence concepts in social networks, and present the relation-algebraic approach to the concepts of power and influence. First, we briefly discuss four kinds of measures of centrality: the
Michel Grabisch, Rudolf Berghammer, Harrie De Swart, Agnieszka Rusinowska   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

To Be or Not to Be Central: On the Stability of Network Centrality Measures in Shakespeare's "Hamlet"

, 2020
Centrality measures derived from character networks can be used to detect the main characters in a play. For example, previous research has shown that characters with high network centrality typically perform the majority of speech acts and appear in most of the scenes. However, one can extract character networks from plays in various ways.
Klimashevskaia, Anastasia, Geiger, Bernhard C., Hagmüller, Martin, Helic, Denis, Fischer, Frank   +4 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Inflow and outflow centrality: novel centrality metrics inspired by graph convolution

Applied Network Science
Centrality metrics quantify a node’s importance within a network based on a node’s connectivity, path position, proximity to other nodes, or influence from neighbors.
Aram Papazian, Volkhard Helms
doaj   +1 more source

A new centrality measure based on neighbor loop structure for network dismantling

Digital Communications and Networks
Nearly all real-world networks are complex networks and usually are in danger of collapse. Therefore, it is crucial to exploit and understand the mechanisms of network attacks and provide better protection for network functionalities. Network dismantling
Qingxia Liu, Bang Wang, Jiming Qi, Xianjun Deng   +3 more
doaj   +1 more source