Results 101 to 110 of about 43,402 (304)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

IOP Measurement and Central Corneal Thickness [PDF]

open access: yesOphthalmology, 2002
In the recent paper by Feltgen and colleagues,1 the intraocular pressure (IOP) was measured by Goldmann applanation tonometry and by using a cannula inserted into the anterior chamber connected with a pressure transducer. Thus, the measurement took place omitting a possible influence of the cornea on the result.
openaire   +2 more sources

Top 10 robotic technologies for each centrality measure.

open access: yes, 2016
Top 10 robotic technologies for each centrality measure.
Woo Jin Lee (735169)   +2 more
core   +1 more source

HellRank: a Hellinger-based centrality measure for bipartite social networks [PDF]

open access: yes, 2017
Measuring centrality in a social network, especially in bipartite mode, poses many challenges, for example, the requirement of full knowledge of the network topology, and the lack of properly detecting top-k behavioral representative users.
Grosu, Radu; orcid:   +11 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

A Study on Linguistic Z-Graph and Its Application in Social Networks

open access: yesMathematics
This paper presents a comprehensive study of the linguistic Z-graph, which is a novel framework designed to analyze linguistic structures within social networks. By integrating concepts from graph theory and linguistics, the linguistic Z-graph provides a
Rupkumar Mahapatra   +4 more
doaj   +1 more source

Computational Analysis of Connectivity Games with Applications to the Investigation of Terrorist Networks

open access: yes, 2013
We study a recently developed centrality metric to identify key players in terrorist organisations due to Lindelauf et al. [2013]. This metric, which involves computation of the Shapley value for connectivity games on graphs proposed by Amer and Gimenez [
Rahwan, Talal   +8 more
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

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