Results 121 to 130 of about 43,402 (304)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Influential Yield Strength of Steel Materials with Return Random Walk Gravity Centrality
MathematicsIn complex networks, important nodes have a significant impact, both functional and structural. From the perspective of data flow pattern detection, the evaluation of the importance of a node in a network, taking into account the role it plays as a ...
Rocío Rodríguez +3 more
doaj +1 more source
Network Centrality in the Human Functional Connectome
, 2012 The network architecture of functional connectivity within the human brain connectome is poorly understood at the voxel level. Here, using resting state functional magnetic resonance imaging data from 1003 healthy adults, we investigate a broad array of ...
Castellanos, F. Xavier +7 more
core
Development and Validation of the Identity Centrality Measure (ICM)
A person’s sense of self or identity can influence how they view themselves, interpret their environment, interact with others, and their overall well-being (Reynolds et al., 2016; Xiao et al., 2016). Identity centrality refers to the relative importance
Donald MacPhail
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Centrality based analysis of amino acids network [PDF]
Network BiologyA network is a crucial asset in biology for capturing and exploring interaction data in biological systems of many types, such as protein-protein communications, amino acid associations, gene regulation, and cellular metabolism.
Chandra Borah, Tazid Ali
doaj
Centrality measure in weighted networks based on an amoeboid algorithm
, 2012 Within network analysis, various measures of node centrality have been developed. In this paper, for weighted networks, a new centrality measure based on an amoeboid algorithm is proposed, which is called Physarum centrality. The measure not only focuses
Y Deng (5282794) +3 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source