Results 131 to 140 of about 43,402 (304)

Identifying Key Nodes in Multiplex Networks Based on Evidence Theory

IEEE Access
Identifying key nodes in multiplex networks is a fundamental problem in the field of network science, which has attracted widespread attention from many scholars.
Laishui Lv, Ting Zhang, Heng Wu, Zijun Zheng, Yinyin Wang, Ye Zhou, Dalal Bardou   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis of amino acid network based on bond energy using graph mining techniques [PDF]

Network Biology
Amino acids are building blocks of proteins which are essential for all biological functions. Each amino acid has different physico-chemical characteristics.
Nasrin Irshad Hussain, Kuntala Boruah, Adil Akhtar   +2 more
doaj  

Who's Who in Crime Network. Wanted the Key Player [PDF]

Criminals are embedded in a network of relationships. Social ties among criminals are modeled by means of a graph where criminals compete for a booty and benefit from local interactions with their neighbours.
Ballester, Coralio, Calvó-Armengol, Antoni, Zenou, Yves   +2 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Novel Convex Combination-Based Mixed Centrality Measure for Identification of Influential Nodes in Complex Networks

IEEE Access
Exploring the significance of popular node’s impact in complex networks yields numerous advantages, such as improving network resilience and accelerating information dissemination.
Buran Basha Mohammad, V. Sateeshkrishna Dhuli, Murali Krishna Enduri, Linga Reddy Cenkeramaddi   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Method of Node Importance Measurement in Software Network Based on the Variations of h-Index

工程科学与技术, 2017
:When new members were involved in the development and maintenance of software projects,they usually need to spendmuch time to understand the architecture and function of the system.To help them understanding a software systemand quickly grasp the system,
DING Yi, LI Bing, CHENG Can, ZHAO Yuqi
doaj  

An improved entropy centrality for detection of spam webpages

Cogent Engineering
Centrality is a popular network analysis concept. Spam nodes in social networks are detected using centrality measures. It classifies a node as influential or anomalous.
Divya S. Raj, Jaganathan B
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source