Results 91 to 100 of about 263,474 (283)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Tensor-Based Framework for Studying Eigenvector Multicentrality in Multilayer Networks

, 2019
Centrality is widely recognized as one of the most critical measures to provide insight in the structure and function of complex networks. While various centrality measures have been proposed for single-layer networks, a general framework for studying ...
Chen, Jiming, He, Shibo, Liu, Yang-Yu, Poor, H. Vincent, Sun, Youxian, Wu, Mincheng, Zhang, Junshan, Zhang, Yongtao   +7 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Assessing the impact of sampling bias on node centralities in synthetic and biological networks

npj Systems Biology and Applications
Centrality measures are crucial for network analysis, offering insights into node importance within complex networks. However, their accuracy is often affected by observational errors and incomplete data.
Ali Salehzadeh-Yazdi, Marc-Thorsten Hütt   +1 more
doaj   +1 more source

Central Actor Identification of Crime Group using Semantic Social Network Analysis

Indonesian Journal of Information Systems, 2019
The Police as law enforcers who authorize in terms of social protection are expected to do both the prevention and investigation efforts also the settlement of criminal cases that occurred in the society.
Sylvert Prian Tahalea, Azhari SN
doaj   +1 more source

Identifying Key Sectors in the Regional Economy: A Network Analysis Approach Using Input-Output Data

, 2020
By applying network analysis techniques to large input-output system, we identify key sectors in the local/regional economy. We overcome the limitations of traditional measures of centrality by using random-walk based measures, as an extension of Blochl ...
DePaolis, Fernando, Kaluza, M. Clara DePaolis, Murphy, Phil   +2 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Correlating densities of centrality and activities in cities : the cases of Bologna (IT) and Barcelona (ES) [PDF]

, 2009
This paper examines the relationship between street centrality and densities of commercial and service activities in cities. The aim is to verify whether a correlation exists and whether some 'secondary' activities, i.e.
Belli, E., Cardillo, A., Cormenzana, B., Càrdenas, F., Latora, L., Latora, V., Porta, S., Rueda, S., Scellato, S., Strano, E., Wang, F.   +10 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Centrality-Based Sombor Index for Network Systems with Applications to Molecular Chemistry and Disease Transmission Networks

Transactions on Fuzzy Sets and Systems
A number is a graphical invariant in graph theory if it is invariant under graph automorphism. In molecular graph theory, graphical invariants are known as topological indices.
Shaikh Ibrahim Abdullah, Maryam Alkandari, Kajal De, Mislav Balkovic   +3 more
doaj