Results 51 to 60 of about 578,628 (285)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficient computation of Harmonic Centrality on large networks: theory and practice [PDF]

, 2022
Progettazione ed implementazione di algoritmi efficienti per il calcolo esatto ed approssimato della Harmonic Centrality su grandi ...
Angriman, Eugenio
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Detecting key actors in interorganizational networks

Management Letters/Cuadernos de Gestión, 2017
Interorganizational network structure can be modified by the actions of key actors. This paper presents a set of strategies for detecting those actors through Social Network Analysis.
Ignacio Ramos Vidal
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Collaborative Visualization: Definition, Challenges, and Research Agenda [PDF]

, 2011
Published online before print July 29, 2011International audienceThe conflux of two growing areas of technology---collaboration and visualization---into a new research direction, collaborative visualization, provides new research challenges.
Cernea, Daniel,, Elmqvist, Niklas, Hagen, Hans, Kwan-liu Ma, Ma, Kwan-Liu, Petra Isenberg, Niklas Elmqvist, null Kwan-Liu Ma, Isenberg, Petra,, Scholtz, Jean,, Hans Hagen, Elmqvist, Niklas,, Isenberg, Petra, Cernea, Daniel, Daniel Cernea, Jean Scholtz, Ma, Kwan-Liu,, Scholtz, Jean, Hagen, Hans,   +18 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Bibliometric Analysis of Forensic Human Remains Identification Literature from 1991 to 2022

Fayixue Zazhi
ObjectiveTo describe the current state of research and future research hotspots through a metrological analysis of the literature in the field of forensic anthropological remains identification research.MethodsThe data retrieved and extracted from the ...
MA Ji-wei, HUANG Ping, ZHANG Ji, YU Hai-xing, CAO Yong-jie, YANG Xiao-tong, XIONG Jian, ZHANG Huai-han, CANG Yong, SHI Ge-fei, CHEN Li-qin   +10 more
doaj   +1 more source