Results 41 to 50 of about 188,378 (311)
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Amalgamating Provincial Health Authorities
Health Reform Observer - Observatoire des Réformes de Santé, 2019 Reflecting the shift away from regionalized health governance in Canada's provinces, the Nova Scotia government consolidated its nine Distinct Health Authorities into the single Nova Scotia Health Authority as of 1 April 2015.
Katherine Fierlbeck
doaj
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Enlargement versus Deepening: The Trade-off Facing Economic Unions [PDF]
This paper analyzes the relationship between the size of an economic union and the degree of policy centralization. We consider a political economy setting in which elected representatives bargain about the degree of centralization within the union.
Gerald Willmann, Oliver Lorz
core +3 more sources
CENTRALISATION OR PERIPHERLISATION? A ‘NEW DEAL” IN URBAN-RURAL RELATIONS [PDF]
Studia Universitatis Babeş-Bolyai: Geographia, 2015 Centralisation or Peripheralization? A ‘New Deal’ in Urban-Rural Relations. Beginning with the new century a new concept of regional planning has established itself in Europe, being strongly related to long-term development, especially in post-industrial
IBOLYA TÖRÖK
doaj
Ecology and Society, 2022 Adaptive water governance involves collaboration among multiple actors, social learning, and flexibility to deal with shocks and surprises. Crises thus become a useful context to assess how the institutional arrangements contribute to adaptation. However,
Micaela Trimble +16 more
doaj +1 more source
(WP 2005-03) Openness, Centralized Wage Bargaining, and Inflation [PDF]
, 2005 This paper develops a model of an open economy containing both sectors in which wages are market-determined and sectors with wage-setting arrangements.
Daniels, Joseph P. +2 more
core +1 more source
Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang +22 more
wiley +1 more source
Shocking the Crowd: The Effect of Censorship Shocks on Chinese Wikipedia
, 2017 Collaborative crowdsourcing has become a popular approach to organizing work across the globe. Being global also means being vulnerable to shocks -- unforeseen events that disrupt crowds -- that originate from any country.
Budak, Ceren +4 more
core +3 more sources
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source