Results 221 to 230 of about 12,577,314 (296)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Publisher Correction: Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2. [PDF]

Nat Commun
Sandmann M, Tajdar S, Sander S, Ruiz Carrillo D, Ganter B, Fischer C, Ocenas M, Etzold S, Pekarek N, Berger J, Meister TL, Selisko B, Canard B, Watt JM, Baszczyňski O, Potter BV, Garcia Alai M, Tidow H, Pfefferle S, Meier C, Fliegert R.   +20 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Temporal Changes in Diagnostic Composition and Treatment Activity Among Mechanically Ventilated ICU Patients Receiving Hyperbaric Oxygen Therapy: An 11-Year Single-Centre Retrospective Study. [PDF]

J Clin Med
Miszewska A, Sobczak O, Góralczyk P, Kot J.   +3 more
europepmc   +1 more source

Job vacancy at the European Centre for Disease Prevention and Control (ECDC).

Euro Surveill
Eurosurveillance editorial team.
europepmc   +1 more source

Variation in capability, organisational structure, and treatment processes for critically ill adults with moderate-to-severe traumatic brain injury in Australia and New Zealand. [PDF]

Crit Care Resusc
Taylor JD, Battistuzzo CR, Kow CY, Moore J, Shim L, Bellapart J, Betteridge T, Bevan RS, Bhonagiri D, Chow A, Flower O, Haydon TP, Jeffcote T, Mak WY, McNamara R, Mistry RN, Morris IS, Senthuran S, Sundararajan K, Warrillow S, Weeden M, Young PJ, Higgins AM, McArthur CJ, Udy AA.   +24 more
europepmc   +1 more source

Regional variability in phytochemical profiles and bioactivities of macerate and decoction extracts from three medicinal plants of Burkina Faso. [PDF]

Front Plant Sci
Ouoba AMA, Sama H, Soré H, Derra AN, Guenné S, Hilou A.   +5 more
europepmc   +1 more source