AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Reproducibility of Centric Relation Techniques by means of Condyle Position Analysis. [PDF]
Galeković NH +3 more
europepmc +1 more source
Les centres d’interprétation dans leur relation à la recherche et à la diffusion [PDF]
Mélanie Bessard, Nolwenn Robine
openalex +1 more source
Anterior temporalis and masseter muscle activity with different centric relation locating methods: A randomized cross-over trial. [PDF]
Nofal AT, Kois JC, Elbasty RS, Zaki AA.
europepmc +1 more source
Three-dimensional assessment of condylar position following orthognathic surgery using the centric relation bite and the ramal reference line: A retrospective clinical study. [PDF]
Lee CH +5 more
europepmc +1 more source
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Accuracy of virtual mounting at centric relation using personalized 3D-printed transfer key: a clinical in vivo study. [PDF]
Huynh NC +8 more
europepmc +1 more source
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Clinical decision of centric relation. [PDF]
Yu H, Yan Z, Xie C, Wu Q.
europepmc +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source

