Results 191 to 200 of about 19,250,496 (285)

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Bearing mechanism of innovative pile-bucket foundations for offshore photovoltaic systems in soft clay under combined loading. [PDF]

Sci Rep
Yu G, Fan K, Gao C, Zhu X.
europepmc   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Lane departure on combined curves: driver heterogeneity, centrifugal risk, and crash prevention. [PDF]

Sci Rep
Wang X, Zhang Y, Li Y, Yi X, Wang X, Hao G.   +5 more
europepmc   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Research on intelligent assembly method of aero-engine deep-cavity nuts based on torque-angle control. [PDF]

Sci Rep
Liu Z, Huang X, Tan J.
europepmc   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Extension of the Moore-Greitzer framework for accurate mathematical modelling of flow instabilities in a low-speed isolated axial compressor rotor blades row. [PDF]

Sci Rep
Katebi M, Zenouz RT.
europepmc   +1 more source

Development of Tilting Strongbox for Centrifuge Model Test

Proceedings of the Japan National Conference on Geotechnical Engineering, 2004
Kuboi, Kimihiko, Suemasa, Naoaki, Azuma, Kenichi, Hoshiya, Hiroshi   +3 more
openaire   +1 more source

Dual‐Functional Membranes With Interfacial MXene/PFSA Nanoarchitectures for Low Hydrogen Permeation in Water Electrolysis and Reduced Vanadium Ion Crossover in Flow Batteries

Advanced Science, EarlyView.
A PFSA/MXene composite membrane is developed for both PEMWE and VRFB applications. MXene incorporation simultaneously enhances proton conductivity and suppresses hydrogen/vanadium crossover. The interaction between MXene functional groups and PFSA's –SO3H reduces the proton diffusion barrier via hydrogen‐bonding networks, while the disordered ...
Panpan Guan, Mingjia Jiang, Yunhu Jiang, Wei Li, Yecheng Zou, Lixiao Zhang, Kaifeng Long, Ziqi Sun, Ting Liao, Hua Kun Liu, Ding Yuan, Dingsheng Wang, Shi Xue Dou, Yuhai Dou   +13 more
wiley   +1 more source