Results 161 to 170 of about 3,262 (203)

Multiphase flow modeling in centrifugal partition chromatography

Journal of Chromatography A, 2011
The separation efficiency in Centrifugal Partition Chromatography (CPC) depends on selection of a suitable biphasic solvent system (distribution ratio, selectivity factor, sample solubility) and is influenced by hydrodynamics in the chambers. Especially the stationary phase retention, the interfacial area for mass transfer and the flow pattern ...
S, Adelmann, C, Schwienheer, G, Schembecker   +2 more
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Flow regimes in centrifugal partition chromatography

AIChE Journal, 1998
AbstractModeling pressure drop, stationary‐phase holdup and separation efficiency in centrifugal partition chromatography (CPC) are hampered by restricted knowledge concerning the flow behavior of the liquid‐liquid two‐phase system. A transparent column (type CPC‐LLN) was constructed to determine the flow behavior as a function of the flow rate ...
M. J. van Buel, F. E. D. van Halsema, L. A. M. van der Wielen, K. Ch. A. M. Luyben   +3 more
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Pressure drop in centrifugal partition chromatography

Journal of Chromatography A, 1997
Abstract Centrifugal partition chromatography (CPC) is more and more becoming a valuable alternative for conventional preparative chromatographic processes. Pressure drop is one of the main limitations hampering optimum performance of a CPC. A model is presented for the pressure drop over a CPC column. The pressure drop consists of two contributions:
Michel J van Buel, Luuk A.M van der Wielen, Karel Ch.A.M Luyben   +2 more
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Centrifugal partition chromatography as a tool for preparative purification of pea albumin with enhanced yields☆

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2007
Publication Inra prise en compte dans l'analyse bibliométrique des publications scientifiques mondiales sur les Fruits, les Légumes et la Pomme de terre. Période 2000-2012.
A Foucault, Alain Foucault
exaly   +2 more sources

Separation of a binary mixture by sequential centrifugal partition chromatography

Journal of Chromatography A, 2012
Sequential centrifugal partition chromatography (sCPC) is a novel continuous cyclic liquid-liquid chromatographic separation technology. Each cycle of the process comprises two steps, which differ by the liquid phase used as mobile phase (upper or lower phase) and its flow direction.
Elisabeth, Hopmann, Mirjana, Minceva
openaire   +2 more sources

Methodology for optimally sized centrifugal partition chromatography columns

Journal of Chromatography A, 2015
Centrifugal Partition Chromatography (CPC) is a separation process based on the partitioning of solutes between two partially miscible liquid phases. There is no solid support for the stationary phase. The centrifugal acceleration is responsible for both stationary phase retention and mobile phase dispersion.
Chollet, Sébastien, Marchal, Luc, Meucci, Jérémy, Renault, Jean-Hugues, Legrand, Jack, Foucault, Alain   +5 more
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Hydrodynamics of Centrifugal Partition Chromatography

1993
The hydrodynamics of Centrifugal Partition Chromatography (CPC), an interesting analytical and preparative scale separation technique, are being investigated for modelling and scale-up. The influences of input variables on hold-up and pressure drop have been measured with an analytical scale CP-chromatograph; a preliminary overview of the first results
R. Meester, M. J. van Buel, L. A. M. van der Wielen, R. Verpoorte, K. Ch. A. M. Luyben   +4 more
openaire   +1 more source

Development of Centrifugal Partition Chromatography for the Purification of Antibody–Drug Conjugates

Analytical Chemistry, 2023
Monoclonal antibody-drug conjugates (ADCs) are an expanding therapeutic class of biomolecules for which relatively few analytical and preparative separation options exist. Purification of ADCs with a specific drug antibody ratio is even more challenging. We report the first application of countercurrent separation (CCS) to this problem.
Prabhakar S. Achanta, J. Brent Friesen, Guy Harris, Gregory K. Webster, Shao-Nong Chen, Guido F. Pauli   +5 more
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Theoretical study of sequential centrifugal partition chromatography

AIChE Journal, 2012
Sequential centrifugal partition chromatography (sCPC) is a novel cyclic liquid–liquid chromatographic process. Each cycle comprises two steps, which differ by the liquid phase used as a mobile phase (upper or lower phase) and its flow direction. The feed is continuously separated into two product streams, which are collected alternately.
Johannes Völkl, Wolfgang Arlt, Mirjana Minceva   +2 more
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Theory and Use of Centrifugal Partition Chromatography

Journal of Liquid Chromatography, 1988
Abstract Centrifugal Partition Chromatography (CPC) is a variant of countercurrent chromatography (CCC). As in CCC, two immiscible liquids are used. The first liquid is the stationary phase, the second is the mobile phase. The liquid stationary phase is held in channels engraved in seveal polychlorotrifluoroethylene (PCTFE) plates. One hundred channels
openaire   +1 more source