Results 281 to 290 of about 495,738 (354)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mass spectrometry protocol for tear fluid proteome profiling and biomarker discovery. [PDF]

STAR Protoc
Juul-Elbaek K, Peiris-Pagès M, Akimov V, Rebollido-Pedrido I, Reardon M, Blagoev B, Hamerlik P.   +6 more
europepmc   +1 more source

Setup and calibration of piles with FBG strain sensors in a geotechnical centrifuge

C.A. Tang, Alec M. Marshall, Charles M. Heron, Andrea Franza, Jingmin Xu   +4 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Protocol for single-base quantification of RNA m5C by pyrosequencing. [PDF]

STAR Protoc
Cayir A, Böttcher Y.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Detection of Autophagy in Human Peripheral Blood Mononuclear Cells Using Guava^® Autophagy and Flow Cytometry. [PDF]

Bio Protoc
Scherer M, Hochecker B, Matt K, Meßmer A, Bergemann J.   +4 more
europepmc   +1 more source

Protocol for nucleo-cytoplasmic fractionation of mammalian cells to study protein translocation via immunoblotting. [PDF]

STAR Protoc
Sharma AL, Zhu E, Padyala R, Parikh K, Tyagi M.   +4 more
europepmc   +1 more source

Protocol for isolating and characterizing extracellular vesicles by ultracentrifugation from bone marrow-derived macrophages. [PDF]

STAR Protoc
Chen Y, Ding R, Miao J, Wang B, Xu J, Wang Z, Sun S, Gu M, Gui Z.   +8 more
europepmc   +1 more source

Protocol to pinpoint oxidized and reduced cysteine residues in brown fat using differential alkylation labeling techniques. [PDF]

STAR Protoc
Oo HK, Galicia-Medina CM, Nishiuchi T, Takayama H, Takamura T.   +4 more
europepmc   +1 more source