Results 61 to 70 of about 246,524 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Open Source Completely 3-D Printable Centrifuge

open access: yesInstruments, 2019
Centrifuges are commonly required devices in medical diagnostics facilities as well as scientific laboratories. Although there are commercial and open source centrifuges, the costs of the former and the required electricity to operate the latter limit ...
Salil S. Sule   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Centrifugal model tests on synchronous deformation of inclinometer pipes in soft soil layers

open access: yesYantu gongcheng xuebao
In geotechnical engineering, the inclinometer pipes are commonly used to monitor shear deformations in soft soil foundations. However, in practical applications, a phenomenon of asynchronous deformation between the inclinometer pipe and the surrounding ...
LI Yongquan 1, HE Xinrong 2, ZHENG Weihao 3, WANG Jiawen 3, LI Guowei 2, 3
doaj   +1 more source

Physical Modelling of Geotechnical Structures in Ports and Offshore

open access: yesPolish Maritime Research, 2017
The physical modelling of subsoil behaviour and soil-structure interaction is essential for the proper design of offshore structures and port infrastructure.
Bałachowski Lech
doaj   +1 more source

About the separation of finely divided particles during centrifugation in liquid media

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2018
This work is devoted to the study of centrifugation processes, which are one of the most complex processes of technology. The use of the action of the centrifugal force field for the separation of heterogeneous liquid systems in a rotor system ...
A. B. Kydyrbekuly   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

SEPARAÇÃO SÓLIDO-LÍQUIDO: CENTRÍFUGAS E PAPÉIS DE FILTRO

open access: yesQuímica Nova, 2015
This work describes the fundamentals and evolution of two current solid-liquid separation methods found in the chemical laboratory: the filter paper and the centrifuge.
Alexander Rangel Bastos   +1 more
doaj   +1 more source

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