Results 141 to 150 of about 23,096 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Physical modelling on unsaturated soils using centrifuge
, 2010 The behavior of geotechnical structures located near the soil surface is highly influenced by unsaturated soil conditions. Some researches about the potentialities of centrifuge modeling of geotechnical problems involving unsaturated soils are presented,
Caicedo, B., Thorel, Luc, Tristancho, J.
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Centrifuge Modeling of Soil Loss Effects on Adjacent Pile Foundations Induced by Tunnel Excavation
Advances in Civil EngineeringIn the context of rapid urbanization and infrastructure development, tunnel excavation has become increasingly popular in urban areas. However, the effect of tunneling on adjacent foundation piles is one of the most serious issues, especially in ...
Wen-Yi Hung +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Centrifuge modeling of heat and mass transfer through soils
, 2003 Migration of heat and mass transfer through geomaterials is of great interest in various civil and electrical engineering projects'. Efforts have been made by the researchers to model heat and mass transfer through geomaterials, particularly through ...
SINGH, DN, KRISHNAIAH, S
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dynamic Excitation for Geotechnical Centrifuge Modelling
, 1981 The method of physical modeling in the centrifuge is growing in acceptance in the U.S.A. following many years of use in U.S.S.R., Denmark, England, Norway, France and Japan. Simulation of dynamic events (machine vibration, wave forces, and earthquake) in
Cheney, J. A.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source