Results 131 to 140 of about 23,096 (306)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Numerical Validation of Fully Coupled Nonlinear Seismic Soil–Pile–Structure Interaction
BuildingsWhile many researchers have broadly studied soil–structure interaction (SSI) problems to comprehend SSI effects on the overall system’s behavior, some critical numerical modeling issues have not been sufficiently investigated to achieve the most accurate
Oğuzhan Çetindemir +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Centrifuge modeling of earth-reinforced retaining walls
, 2013 This paper is on the centrifuge modeling of reinforced soil retaining walls with modular blocks facing. The influence of design parameters, such as length and vertical spacing of reinforcement, on the behaviour of the structure was investigated.
M. Iacorossi +3 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Soil Liquefaction – Centrifuge and Fluid Dynamics Modeling
, 2019 9:00 AM9:00am-11:00amGraduateSoil liquefaction is a phenomenon, happens during earthquakes in loose saturated soils causing the soil to lose its strength.
BANERJEE, SOHAM
core
The Effect of Lateral Loading Parameters on Monopile Behavior Based on Physical Modeling
نشریه مهندسی دریا, 2019 Monopiles are the most common type of foundation for offshore wind turbines (OWT). Monopiles have been used in more than 80% of the offshore wind turbines.
Mahdi Shahidikhah +2 more
doaj