Results 111 to 120 of about 2,483,895 (292)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2002 Geotechnical centrifuge modelling is used for a wide range of investigations, which cover almost the whole field of geotechnical engineering problems. Independently of the question to be answered, the basis of the centrifuge modelling technique is the ...
Laue, Jan,
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Centrifuge Study on the Influence of Tunnel Excavation on Piles in Sand [PDF]
, 2020 © 2020 American Society of Civil Engineers. Tunneling-induced ground movements can affect the equilibrium state of an existing pile, causing uneven settlement among pile groups and damage to connected structures.
Song, Geyang, Marshall, Alec M.
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Centrifuge modeling of cadmium migration in saturated and unsaturated soils
, 2005 Researchers recently have come to recognize that geotechnical centrifuge can provide a powerful experimental tool for investigating the flow and transport of inorganic contaminants in soils.
Lo, Irene M.C. +2 more
core +1 more source
Centrifuge modeling of pile-supported embankment on soft soil base for highway widening
Soils and FoundationsThe pile-supported embankment has been widely adopted in highway widening projects. There is often significant differential settlement between the new and old embankments.
Tianyi Chen, Ga Zhang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Centrifuge modeling to support the design of subsea pipelines
, 2012 Offshore geotechnical engineering is characterized by unusual soil and loading conditions, a continuously moving frontier resulting in the requirement for innovative geotechnical solutions, and the very high cost associated with in-situ soil ...
D. J. White +3 more
core +1 more source
Centrifuge modeling of LNAPL transport in partially saturated sand
, 1999 Model tests were performed at the Geotechnical Centrifuge Facility of Delft University of Technology, The Netherlands, to examine the mechanics of light nonaqueous phase liquid (LNAPL) movement in a partially saturated porous granular medium.
Selvadurai, A.P.S. +2 more
core +1 more source