Results 171 to 180 of about 1,590,241 (290)

Stress Transfer Around Cross Passages in Shallow Tunnels: Effects of Volume Loss and Cross Passage Shape. [PDF]

Geotech Geol Eng (Dordr)
Saif A, Hussain M, Soranzo E, Wu W.
europepmc   +1 more source

Modeling for control of centrifugal compressors

, 2013
Downsizing and turbocharging of engines provide a way to meet increasing demands for efficiency and performance in the automotive industry. An engine design is a result of compromises, e.g. the selection of charging system, and the trend is to reduce these compromises by increasing system complexity.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy. [PDF]

Pharmaceutics
Hunachagi S, Alqudihi HH, AbdulAzeez S, Borgio JF, Almohazey D.   +4 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Protocol for generating human iPSC-derived cardiomyocytes using VCAM1-based sorting and micropatterned culture. [PDF]

STAR Protoc
Furtado M, Ribeiro M, Carvalho T, Martins S, Carmo-Fonseca M.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Metabolic Modelling Facilitates the Design of Synthetic Communities by Simplifying Natural Microbial Communities. [PDF]

Environ Microbiol
Lin X, Ding S, Li W, Yang B, Chen Y, Shen Z, Jiang J, Chen C, Xu X.   +8 more
europepmc   +1 more source

Centrifugal Modelling of Rockfall Events

Centrifugal Modelling of Rockfall Events
identifier:oai:t2r2.star.titech.ac.jp ...
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source